5-ethyl-2-(2-isopropoxy-6-(4-(methylsulfonyl)phenoxy)pyridin-4-yl)-4-(4-methoxybenzyloxy)pyrimidine

Base Information

Chemical Name:5-ethyl-2-(2-isopropoxy-6-(4-(methylsulfonyl)phenoxy)pyridin-4-yl)-4-(4-methoxybenzyloxy)pyrimidine
CAS No.:1352571-52-8
Molecular Formula:C₂₉H₃₁N₃O₆S
Molecular Weight:549.648
Hs Code.:

Synonyms:5-ethyl-2-(2-isopropoxy-6-(4-(methylsulfonyl)phenoxy)pyridin-4-yl)-4-(4-methoxybenzyloxy)pyrimidine

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Chemical Property of 5-ethyl-2-(2-isopropoxy-6-(4-(methylsulfonyl)phenoxy)pyridin-4-yl)-4-(4-methoxybenzyloxy)pyrimidine

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Technology Process of 5-ethyl-2-(2-isopropoxy-6-(4-(methylsulfonyl)phenoxy)pyridin-4-yl)-4-(4-methoxybenzyloxy)pyrimidine

There total 7 articles about 5-ethyl-2-(2-isopropoxy-6-(4-(methylsulfonyl)phenoxy)pyridin-4-yl)-4-(4-methoxybenzyloxy)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352570-81-0
2-chloro-5-ethyl-4-(4-methoxybenzyloxy)pyrimidine

: 1352571-51-7
2-isopropoxy-6-(4-(methylsulfonyl)phenoxy)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

: 1352571-52-8
5-ethyl-2-(2-isopropoxy-6-(4-(methylsulfonyl)phenoxy)pyridin-4-yl)-4-(4-methoxybenzyloxy)pyrimidine

Guidance literature:: With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; acetonitrile; at 140 ℃; for 0.5h; Inert atmosphere; Microwave irradiation; Sealed tube;

Reference yield:

: 1073-72-9
4-hydroxythioanisole

: 1352571-52-8
5-ethyl-2-(2-isopropoxy-6-(4-(methylsulfonyl)phenoxy)pyridin-4-yl)-4-(4-methoxybenzyloxy)pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 90 °C / Sealed tube

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C

2.2: 120 °C / Sealed tube

3.1: Oxone / ethyl acetate; water; methanol / 6 h / 20 °C

4.1: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tert-butyl methyl ether / 10 h / 100 °C / Inert atmosphere; Microwave irradiation; Sealed tube

5.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile; water / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation; Sealed tube

With Oxone; sodium hydride; sodium carbonate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; methanol; tert-butyl methyl ether; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; mineral oil; 5.1: Suzuki Coupling;

Reference yield:

: 1513-65-1
2,6-difluoro pyridine

: 1352571-52-8
5-ethyl-2-(2-isopropoxy-6-(4-(methylsulfonyl)phenoxy)pyridin-4-yl)-4-(4-methoxybenzyloxy)pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 90 °C / Sealed tube

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C

2.2: 120 °C / Sealed tube

3.1: Oxone / ethyl acetate; water; methanol / 6 h / 20 °C

4.1: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tert-butyl methyl ether / 10 h / 100 °C / Inert atmosphere; Microwave irradiation; Sealed tube

5.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile; water / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation; Sealed tube

With Oxone; sodium hydride; sodium carbonate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; methanol; tert-butyl methyl ether; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; mineral oil; 5.1: Suzuki Coupling;