4-hydroxy-6-phenyl-hexa-2,5-diynoic acid ethyl ester

Base Information

Chemical Name:4-hydroxy-6-phenyl-hexa-2,5-diynoic acid ethyl ester
CAS No.:553636-87-6
Molecular Formula:C₁₄H₁₂O₃
Molecular Weight:228.247
Hs Code.:

Synonyms:4-hydroxy-6-phenyl-hexa-2,5-diynoic acid ethyl ester

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Chemical Property of 4-hydroxy-6-phenyl-hexa-2,5-diynoic acid ethyl ester

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Technology Process of 4-hydroxy-6-phenyl-hexa-2,5-diynoic acid ethyl ester

There total 1 articles about 4-hydroxy-6-phenyl-hexa-2,5-diynoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 2579-22-8
Phenylpropargyl aldehyde

: 623-47-2
propynoic acid ethyl ester

: 553636-87-6
4-hydroxy-6-phenyl-hexa-2,5-diynoic acid ethyl ester

Guidance literature:: propynoic acid ethyl ester; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

Phenylpropargyl aldehyde; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;
DOI:10.1016/S0040-4020(03)00244-8

Reference yield: 95.0%

: 553636-87-6
4-hydroxy-6-phenyl-hexa-2,5-diynoic acid ethyl ester

: 311348-65-9
4-oxo-6-phenyl-hexa-2,5-diynoic acid ethyl ester

Guidance literature:: With 2,2,6,6-tetramethyl-piperidine-N-oxyl; oxone; tetrabutylammomium bromide; In toluene; at 20 ℃; for 5h;
DOI:10.1016/S0040-4020(03)00244-8

Reference yield:

: 553636-87-6
4-hydroxy-6-phenyl-hexa-2,5-diynoic acid ethyl ester

: 5-phenylethynyl-2H-pyrazole-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / Oxone(R); tetrabutylammonium bromide; 2,2,6,6-tetramethyl-1-piperidinyloxy radical / toluene / 5 h / 20 °C

2: 49 percent / hydrazine hydrate / ethanol / 1 h / Heating

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; oxone; tetrabutylammomium bromide; hydrazine hydrate; In ethanol; toluene;
DOI:10.1016/S0040-4020(03)00244-8