methyl 2-methylene-3-oxo-1-(4-(trifluoromethyl)phenyl)butyl(tosyl)carbamate

Base Information

Chemical Name:methyl 2-methylene-3-oxo-1-(4-(trifluoromethyl)phenyl)butyl(tosyl)carbamate
CAS No.:1330174-04-3
Molecular Formula:C₂₁H₂₀F₃NO₅S
Molecular Weight:455.455
Hs Code.:

Synonyms:methyl 2-methylene-3-oxo-1-(4-(trifluoromethyl)phenyl)butyl(tosyl)carbamate

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Chemical Property of methyl 2-methylene-3-oxo-1-(4-(trifluoromethyl)phenyl)butyl(tosyl)carbamate

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Technology Process of methyl 2-methylene-3-oxo-1-(4-(trifluoromethyl)phenyl)butyl(tosyl)carbamate

There total 2 articles about methyl 2-methylene-3-oxo-1-(4-(trifluoromethyl)phenyl)butyl(tosyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1308286-05-6
tert-butyl (2-methylene-3-oxo-1-(4-(trifluoromethyl)phenyl)butyl) carbonate

: 14437-03-7
methyl tosylcarbamate

: 1330174-04-3
methyl 2-methylene-3-oxo-1-(4-(trifluoromethyl)phenyl)butyl(tosyl)carbamate

Guidance literature:: With 6'-N-phenylformamide-β-ICD; In tetrahydrofuran; at 20 ℃; for 72h; optical yield given as %ee;
DOI:10.1002/ejoc.201100501

Reference yield:

: 3-(α-hydroxy-p-trifluoromethylbenzyl)but-3-en-2-one

: 1330174-04-3
methyl 2-methylene-3-oxo-1-(4-(trifluoromethyl)phenyl)butyl(tosyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap / dichloromethane / 20 °C

2: 6'-N-phenylformamide-β-ICD / tetrahydrofuran / 72 h / 20 °C

With dmap; 6'-N-phenylformamide-β-ICD; In tetrahydrofuran; dichloromethane;
DOI:10.1002/ejoc.201100501