3-[4-(3,3-difluoroazetidin-1-yl)cyclohexen-1-yl]-1-(4-nitrophenyl)indole

Base Information

Chemical Name:3-[4-(3,3-difluoroazetidin-1-yl)cyclohexen-1-yl]-1-(4-nitrophenyl)indole
CAS No.:1416891-88-7
Molecular Formula:C₂₃H₂₁F₂N₃O₂
Molecular Weight:409.435
Hs Code.:

Synonyms:3-[4-(3,3-difluoroazetidin-1-yl)cyclohexen-1-yl]-1-(4-nitrophenyl)indole

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Chemical Property of 3-[4-(3,3-difluoroazetidin-1-yl)cyclohexen-1-yl]-1-(4-nitrophenyl)indole

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Technology Process of 3-[4-(3,3-difluoroazetidin-1-yl)cyclohexen-1-yl]-1-(4-nitrophenyl)indole

There total 3 articles about 3-[4-(3,3-difluoroazetidin-1-yl)cyclohexen-1-yl]-1-(4-nitrophenyl)indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1416891-87-6
3-[4-(3,3-difluoroazetidin-1-yl)cyclohexen-1-yl]-1H-indole

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1416891-88-7
3-[4-(3,3-difluoroazetidin-1-yl)cyclohexen-1-yl]-1-(4-nitrophenyl)indole

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 18h;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1416891-88-7
3-[4-(3,3-difluoroazetidin-1-yl)cyclohexen-1-yl]-1-(4-nitrophenyl)indole

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine

1.3: 3 h / 20 °C

2.1: potassium hydroxide / methanol / 18 h / 60 °C / Sealed tube

3.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 60 °C

With methanol; sodium tris(acetoxy)borohydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1416892-22-2
4-(3,3-difluoroazetidin-1-yl)cyclohexanone

: 1416891-88-7
3-[4-(3,3-difluoroazetidin-1-yl)cyclohexen-1-yl]-1-(4-nitrophenyl)indole

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / methanol / 18 h / 60 °C / Sealed tube

2: caesium carbonate / N,N-dimethyl-formamide / 18 h / 60 °C

With caesium carbonate; potassium hydroxide; In methanol; N,N-dimethyl-formamide;