1-[4-[3-[4-(3,3-difluoroazetidin-1-yl)cyclohexyl]indol-1-yl]phenyl]-3-(3-pyridylmethyl)urea

Base Information

Chemical Name:1-[4-[3-[4-(3,3-difluoroazetidin-1-yl)cyclohexyl]indol-1-yl]phenyl]-3-(3-pyridylmethyl)urea
CAS No.:1416890-88-4
Molecular Formula:C₃₀H₃₁F₂N₅O
Molecular Weight:515.606
Hs Code.:

Synonyms:1-[4-[3-[4-(3,3-difluoroazetidin-1-yl)cyclohexyl]indol-1-yl]phenyl]-3-(3-pyridylmethyl)urea

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Chemical Property of 1-[4-[3-[4-(3,3-difluoroazetidin-1-yl)cyclohexyl]indol-1-yl]phenyl]-3-(3-pyridylmethyl)urea

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Technology Process of 1-[4-[3-[4-(3,3-difluoroazetidin-1-yl)cyclohexyl]indol-1-yl]phenyl]-3-(3-pyridylmethyl)urea

There total 5 articles about 1-[4-[3-[4-(3,3-difluoroazetidin-1-yl)cyclohexyl]indol-1-yl]phenyl]-3-(3-pyridylmethyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 3731-52-0
3-Aminomethylpyridine

: 1416891-89-8
cis-4-[3-[4-(3,3-difluoroazetidin-1-yl)cyclohexyl]indol-1-yl]aniline

: 503-38-8
trichloromethyl chloroformate

: 1416890-88-4
1-[4-[3-[4-(3,3-difluoroazetidin-1-yl)cyclohexyl]indol-1-yl]phenyl]-3-(3-pyridylmethyl)urea

Guidance literature:: cis-4-[3-[4-(3,3-difluoroazetidin-1-yl)cyclohexyl]indol-1-yl]aniline; trichloromethyl chloroformate; With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

3-Aminomethylpyridine; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1416890-88-4
1-[4-[3-[4-(3,3-difluoroazetidin-1-yl)cyclohexyl]indol-1-yl]phenyl]-3-(3-pyridylmethyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine

1.3: 3 h / 20 °C

2.1: potassium hydroxide / methanol / 18 h / 60 °C / Sealed tube

3.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 60 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 2068.65 Torr

5.1: triethylamine / dichloromethane / 0.5 h / 0 °C

5.2: 3 h / 0 - 20 °C

With methanol; hydrogen; sodium tris(acetoxy)borohydride; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1416891-88-7
3-[4-(3,3-difluoroazetidin-1-yl)cyclohexen-1-yl]-1-(4-nitrophenyl)indole

: 1416890-88-4
1-[4-[3-[4-(3,3-difluoroazetidin-1-yl)cyclohexyl]indol-1-yl]phenyl]-3-(3-pyridylmethyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 2068.65 Torr

2.1: triethylamine / dichloromethane / 0.5 h / 0 °C

2.2: 3 h / 0 - 20 °C

With hydrogen; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane;