(2R)-2-<(tert-Butyloxycarbonyl)amino>-N-(4-fluoro-3-nitrophenethyl)-p-hydroxyphenylacetamide

Base Information

Chemical Name:(2R)-2-<(tert-Butyloxycarbonyl)amino>-N-(4-fluoro-3-nitrophenethyl)-p-hydroxyphenylacetamide
CAS No.:160877-33-8
Molecular Formula:C₂₁H₂₄FN₃O₆
Molecular Weight:433.436
Hs Code.:

Synonyms:(2R)-2-<(tert-Butyloxycarbonyl)amino>-N-(4-fluoro-3-nitrophenethyl)-p-hydroxyphenylacetamide

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Chemical Property of (2R)-2-<(tert-Butyloxycarbonyl)amino>-N-(4-fluoro-3-nitrophenethyl)-p-hydroxyphenylacetamide

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Technology Process of (2R)-2-<(tert-Butyloxycarbonyl)amino>-N-(4-fluoro-3-nitrophenethyl)-p-hydroxyphenylacetamide

There total 8 articles about (2R)-2-<(tert-Butyloxycarbonyl)amino>-N-(4-fluoro-3-nitrophenethyl)-p-hydroxyphenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 27460-85-1
N-(tert-butoxycarbonyl)-D-(4-hydroxyphenyl)glycine

: 157662-78-7
2-(4-Fluoro-3-nitro-phenyl)-ethylamine

: 160877-33-8
(2R)-2-<(tert-Butyloxycarbonyl)amino>-N-(4-fluoro-3-nitrophenethyl)-p-hydroxyphenylacetamide

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; for 12h; Ambient temperature;
DOI:10.1021/jo00098a010

Reference yield:

: 42564-51-2
4-fluoro-3-nitrobenzaldehyde

: 160877-33-8
(2R)-2-<(tert-Butyloxycarbonyl)amino>-N-(4-fluoro-3-nitrophenethyl)-p-hydroxyphenylacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: NaBH₄

2: PBr₃

3: 83.9 percent / acetonitrile / 4 h / Ambient temperature

4: 50.2 percent / NaBH₄, TFA / tetrahydrofuran / 15 h / Ambient temperature

5: 72 percent / DCC, 1-hydroxybenzotriazole / dimethylformamide; CH₂Cl₂ / 12 h / Ambient temperature

With sodium tetrahydroborate; phosphorus tribromide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00098a010

Reference yield:

: 20274-69-5
(4-fluoro-3-nitrophenyl)methanol

: 160877-33-8
(2R)-2-<(tert-Butyloxycarbonyl)amino>-N-(4-fluoro-3-nitrophenethyl)-p-hydroxyphenylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: PBr₃

2: 83.9 percent / acetonitrile / 4 h / Ambient temperature

3: 50.2 percent / NaBH₄, TFA / tetrahydrofuran / 15 h / Ambient temperature

4: 72 percent / DCC, 1-hydroxybenzotriazole / dimethylformamide; CH₂Cl₂ / 12 h / Ambient temperature

With sodium tetrahydroborate; phosphorus tribromide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00098a010