4-Fluoro-3-nitrobenzeneethanamine

Base Information

Chemical Name:4-Fluoro-3-nitrobenzeneethanamine
CAS No.:157662-78-7
Molecular Formula:C₈H₉FN₂O₂
Molecular Weight:184.17
Hs Code.:
DSSTox Substance ID:DTXSID701299126

Synonyms:157662-78-7;SCHEMBL16654008;4-Fluoro-3-nitrobenzeneethanamine;DTXSID701299126;2-(4-fluoro-3-nitrophenyl)ethan-1-amine;EN300-1835868

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Fluoro-3-nitrobenzeneethanamine

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:184.06480570
Heavy Atom Count:13
Complexity:184

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=C(C=C1CCN)[N+](=O)[O-])F

Technology Process of 4-Fluoro-3-nitrobenzeneethanamine

There total 7 articles about 4-Fluoro-3-nitrobenzeneethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 157662-77-6
2-(4-fluoro-3-nitrophenyl)acetonitrile

: 157662-78-7
2-(4-Fluoro-3-nitro-phenyl)-ethylamine

Guidance literature:: With lithium aluminium tetrahydride; aluminium trichloride;
DOI:10.1039/c39940000439

Reference yield:

: 42564-51-2
4-fluoro-3-nitrobenzaldehyde

: 157662-78-7
2-(4-Fluoro-3-nitro-phenyl)-ethylamine

Guidance literature:: Multi-step reaction with 4 steps

1: NaBH₄

2: PBr₃

3: 83.9 percent / acetonitrile / 4 h / Ambient temperature

4: 50.2 percent / NaBH₄, TFA / tetrahydrofuran / 15 h / Ambient temperature

With sodium tetrahydroborate; phosphorus tribromide; trifluoroacetic acid; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jo00098a010

Reference yield:

: 20274-69-5
(4-fluoro-3-nitrophenyl)methanol

: 157662-78-7
2-(4-Fluoro-3-nitro-phenyl)-ethylamine

Guidance literature:: Multi-step reaction with 3 steps

1: PBr₃

2: 83.9 percent / acetonitrile / 4 h / Ambient temperature

3: 50.2 percent / NaBH₄, TFA / tetrahydrofuran / 15 h / Ambient temperature

With sodium tetrahydroborate; phosphorus tribromide; trifluoroacetic acid; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jo00098a010