methanesulfonic acid 3-(3-ethyloxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalene-7-ylcarbamoyl)-2-fluorobenzyl ester

Base Information

Chemical Name:methanesulfonic acid 3-(3-ethyloxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalene-7-ylcarbamoyl)-2-fluorobenzyl ester
CAS No.:1260236-47-2
Molecular Formula:C₃₀H₃₂FNO₈S₂
Molecular Weight:617.716
Hs Code.:

methanesulfonic acid 3-(3-ethyloxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalene-7-ylcarbamoyl)-2-fluorobenzyl ester

Synonyms:methanesulfonic acid 3-(3-ethyloxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalene-7-ylcarbamoyl)-2-fluorobenzyl ester

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Chemical Property of methanesulfonic acid 3-(3-ethyloxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalene-7-ylcarbamoyl)-2-fluorobenzyl ester

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Technology Process of methanesulfonic acid 3-(3-ethyloxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalene-7-ylcarbamoyl)-2-fluorobenzyl ester

There total 8 articles about methanesulfonic acid 3-(3-ethyloxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalene-7-ylcarbamoyl)-2-fluorobenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.8%

: 1260236-46-1
N-(3-ethoxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalene-7-yl)-2-fluoro-3-hydroxymethylbenzamide

: 124-63-0
methanesulfonyl chloride

: 1260236-47-2
methanesulfonic acid 3-(3-ethyloxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalene-7-ylcarbamoyl)-2-fluorobenzyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

Reference yield:

: 481075-37-0
2-fluoro-3-(hydroxymethyl)benzoic acid

: 1260236-47-2
methanesulfonic acid 3-(3-ethyloxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalene-7-ylcarbamoyl)-2-fluorobenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 2 h / 20 °C

2: triethylamine / dichloromethane / 0.5 h / 0 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;

Reference yield:

: 914301-44-3
2-fluoroisophthalic acid monomethyl ester

: 1260236-47-2
methanesulfonic acid 3-(3-ethyloxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalene-7-ylcarbamoyl)-2-fluorobenzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 4-methyl-morpholine / dichloromethane / 0.5 h / 0 °C

1.2: 1 h / 0 °C

1.3: 1 h / 20 °C

2.1: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / Reflux

3.1: sodium hydroxide; water / 40 h / Reflux

3.2: 0 °C / pH 2

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 2 h / 20 °C

5.1: triethylamine / dichloromethane / 0.5 h / 0 °C

With 4-methyl-morpholine; sodium tetrahydroborate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane;