3-cyclopropyl-1-(2-fluorophenyl)-3-oxopropyl methanesulfonate

Base Information

• Chemical Name: 3-cyclopropyl-1-(2-fluorophenyl)-3-oxopropyl methanesulfonate
• CAS No.: 1100905-46-1
• Molecular Formula: C₁₂H₁₃FO₄S
• Molecular Weight: 272.297
• Mol file: 1100905-46-1.mol

Synonyms:3-cyclopropyl-1-(2-fluorophenyl)-3-oxopropyl methanesulfonate

Chemical Property of 3-cyclopropyl-1-(2-fluorophenyl)-3-oxopropyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-cyclopropyl-1-(2-fluorophenyl)-3-oxopropyl methanesulfonate

There total 1 articles about 3-cyclopropyl-1-(2-fluorophenyl)-3-oxopropyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-hydroxy-1-cyclopropyl-2-(2-fluorophenyl)ethanone (1100905-45-0) + methanesulfonyl chloride (124-63-0) → 3-cyclopropyl-1-(2-fluorophenyl)-3-oxopropyl methanesulfonate (1100905-46-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 2 ℃;

Reference yield: 12.0%

3-cyclopropyl-1-(2-fluorophenyl)-3-oxopropyl methanesulfonate (1100905-46-1) + 2-oxo-2,4,5,6,7a-hexahydrothieno[3,2-c]pyridine hydrochloride (951380-43-1) + acetic anhydride (108-24-7) → prasugel (150322-43-3)

Guidance literature:

3-cyclopropyl-1-(2-fluorophenyl)-3-oxopropyl methanesulfonate; 2-oxo-2,4,5,6,7a-hexahydrothieno[3,2-c]pyridine hydrochloride; With tetraethylammonium bromide; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 1.5h;

acetic anhydride; With N-ethyl-N,N-diisopropylamine; dmap; In acetonitrile; at 20 ℃; for 2h;

Reference yield:

5,6,7,7a-tetrahydro-4H-thieno[3,2-c]pyridin-2-one p-toluenesulfonate (178688-49-8) + 3-cyclopropyl-1-(2-fluorophenyl)-3-oxopropyl methanesulfonate (1100905-46-1) + acetic anhydride (108-24-7) → prasugel (150322-43-3)

Guidance literature:

5,6,7,7a-tetrahydro-4H-thieno[3,2-c]pyridin-2-one p-toluenesulfonate; 3-cyclopropyl-1-(2-fluorophenyl)-3-oxopropyl methanesulfonate; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 1.5h;

acetic anhydride; With N-ethyl-N,N-diisopropylamine; dmap; In acetonitrile; at 20 ℃; for 2h;

upstream raw materials:

2-hydroxy-1-cyclopropyl-2-(2-fluorophenyl)ethanone

methanesulfonyl chloride

Downstream raw materials:

5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

prasugel

5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate benzene sulfonate

prasugrel hydrobromide

Refernces