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Prasugrel

Base Information Edit
  • Chemical Name:Prasugrel
  • CAS No.:150322-43-3
  • Molecular Formula:C20H20FNO3S
  • Molecular Weight:373.448
  • Hs Code.:29349990
  • European Community (EC) Number:801-962-1
  • UNII:34K66TBT99
  • DSSTox Substance ID:DTXSID70861544
  • Nikkaji Number:J1.292.848C
  • Wikipedia:Prasugrel
  • Wikidata:Q416232
  • NCI Thesaurus Code:C81566
  • RXCUI:613391
  • Pharos Ligand ID:7RJP74QP5DDH
  • Metabolomics Workbench ID:43663
  • ChEMBL ID:CHEMBL1201772
  • Mol file:150322-43-3.mol
Prasugrel

Synonyms:640315, LY;747, CS;CS 747;CS-747;CS747;Effient;efient;HCl, Prasugrel;Hydrochloride, Prasugrel;LY 640315;LY-640315;LY640315;prasugrel;Prasugrel HCl;Prasugrel Hydrochloride

Suppliers and Price of Prasugrel
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • Prasugrel
  • 1g
  • $ 275.00
  • Tocris
  • Prasugrel ≥98%(HPLC)
  • 10
  • $ 61.00
  • Tocris
  • Prasugrel ≥98%(HPLC)
  • 50
  • $ 253.00
  • TCI Chemical
  • Prasugrel >98.0%(HPLC)(T)
  • 200mg
  • $ 137.00
  • Sigma-Aldrich
  • Prasugrel ≥98% (HPLC)
  • 10mg
  • $ 94.80
  • Sigma-Aldrich
  • Prasugrel ≥98% (HPLC)
  • 50mg
  • $ 372.00
  • Medical Isotopes, Inc.
  • (?±)-Prasugrel-d3(acetate-d3)
  • 10 mg
  • $ 480.00
  • Medical Isotopes, Inc.
  • (?±)-Prasugrel-d3(acetate-d3)
  • 50 mg
  • $ 1280.00
  • DC Chemicals
  • Prasugrel >98%
  • 250 mg
  • $ 500.00
  • CSNpharm
  • Prasugrel
  • 25mg
  • $ 35.00
Total 228 raw suppliers
Chemical Property of Prasugrel Edit
Chemical Property:
  • Appearance/Colour:White solid 
  • Vapor Pressure:0mmHg at 25°C 
  • Melting Point:120.0 to 124.0 °C 
  • Refractive Index:1.619 
  • Boiling Point:493.5 °C at 760 mmHg 
  • PKA:3.65±0.20(Predicted) 
  • Flash Point:252.3 °C 
  • PSA:74.85000 
  • Density:1.347 g/cm3 
  • LogP:3.82890 
  • Storage Temp.:2-8°C 
  • Solubility.:DMSO: >5mg/mL (warmed at 60 °C) 
  • XLogP3:3.6
  • Hydrogen Bond Donor Count:0
  • Hydrogen Bond Acceptor Count:6
  • Rotatable Bond Count:6
  • Exact Mass:373.11479284
  • Heavy Atom Count:26
  • Complexity:555
Purity/Quality:

98%, *data from raw suppliers

Prasugrel *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
  • Safety Statements: 24/25 
MSDS Files:

SDS file from LookChem

Useful:
  • Drug Classes:Antithrombotic Agents
  • Canonical SMILES:CC(=O)OC1=CC2=C(S1)CCN(C2)C(C3=CC=CC=C3F)C(=O)C4CC4
  • Recent ClinicalTrials:Replication of the TRITON-TIMI Antiplatelet Trial in Healthcare Claims Data
  • Recent EU Clinical Trials:Ischemic and bleeding outcomes after angiolite stent implantation and an abbreviated dual antiplatelet therapy. A 2x2 factorial, all-comer, multicenter, randomized controlled trial: Angiodapt.
  • Recent NIPH Clinical Trials:ShorT and OPtimal duration of Dual AntiPlatelet Therapy-3 study
  • Description Prasugrel is a third-generation thienopyridine that has been developed and launched for the prevention of atherothrombotic events in patients with ACS or following PCI. While the second-generation agent clopidogrel was an improvement over the first-generation ticlopidine, which suffered from gastrointestinal adverse effects and the risk of neutropenia with prolonged use, its delayed onset of action and considerable interpatient variability prompted the search for the next-generation thienopyridine. The mechanism of action of these platelet inhibitors involves initial biological activation to a sulfhydryl metabolite that irreversibly binds to the P2γ12 receptor on platelets via disulfide formation, thereby preventing platelet activation and aggregation by the endogenous agonist adenosine diphosphate (ADP). The advantage of prasugrel over its predecessors is its more efficient and consistent absorption and rapid conversion to its active metabolite. Co-administration of thienopyridines with acetylsalicylic acid (aspirin), an inhibitor of the synthesis of the platelet aggregation mediator thromboxane A2, is an effective antiplatelet strategy and joins antagonists of glycoprotein IIb/IIIa, which target the final step in platelet aggregation, in the medical arsenal combating atherothrombotic events.
  • Uses Prasugrel is a platelet inhibitor that reduces aggregation of platelets by being a P2Y12(ADP receptor) inhibitor. Inhibits platelet aggregation (platelet ADPP 2Y12 antagonist).
  • Clinical Use Prasugrel is a platelet inhibitor developed by Daiichi Sankyo Co. and is marketed in the United States in cooperation with Eli Lilly and Company for acute coronary syndromes planned for percutaneous coronary intervention (PCI). Prasugrel was approved for use in Europe in February 2009, and is currently available in the UK. In the U.S. prasugrel is also approved for the reduction of thrombotic cardiovascular events, including stent thrombosis, in patients with acute coronary syndrome who are to be managed with PCI. Prasugrel is a member of the thienopyridine class of ADP receptor inhibitors, and irreversibly binds to P2Y12 receptors.
  • Drug interactions Potentially hazardous interactions with other drugs Anticoagulants: enhanced anticoagulant effect with coumarins and phenindione.
Technology Process of Prasugrel

There total 87 articles about Prasugrel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one; acetyl chloride; With acetic acid; In toluene; at 20 ℃; Inert atmosphere;
With sodium hydrogencarbonate; In water; toluene;
Guidance literature:
With triethylamine; sodium hydroxide; In water; ethyl acetate; at 7 - 50 ℃; pH=2.8; Temperature; pH-value;
Guidance literature:
2-(tert-butyldimethylsilyloxy)-5-(α-cyclopropylformyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine; With dmap; triethylamine; In acetone; at 0 ℃; for 0.166667h;
acetic anhydride; In acetone; Solvent; Temperature;
Refernces Edit
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