N²-(2-methylpropanoyl)-2',3',5'-tris-O-(2-methylpropanoyl)-O⁶-(2''',4''',6'''-triisopropylphenylsulfonyl)guanosine

Base Information

• Chemical Name: N²-(2-methylpropanoyl)-2',3',5'-tris-O-(2-methylpropanoyl)-O⁶-(2''',4''',6'''-triisopropylphenylsulfonyl)guanosine
• CAS No.: 133324-34-2
• Molecular Formula: C₄₁H₅₉N₅O₁₁S
• Molecular Weight: 830.012

Synonyms:N²-(2-methylpropanoyl)-2',3',5'-tris-O-(2-methylpropanoyl)-O⁶-(2''',4''',6'''-triisopropylphenylsulfonyl)guanosine

Chemical Property of N²-(2-methylpropanoyl)-2',3',5'-tris-O-(2-methylpropanoyl)-O⁶-(2''',4''',6'''-triisopropylphenylsulfonyl)guanosine

Chemical Property:

Purity/Quality:

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Technology Process of N²-(2-methylpropanoyl)-2',3',5'-tris-O-(2-methylpropanoyl)-O⁶-(2''',4''',6'''-triisopropylphenylsulfonyl)guanosine

There total 3 articles about N²-(2-methylpropanoyl)-2',3',5'-tris-O-(2-methylpropanoyl)-O⁶-(2''',4''',6'''-triisopropylphenylsulfonyl)guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.5%

N2-(2-methylpropanoyl)-2',3',5'-tris-O-(2-methylpropanoyl)guanosine (70337-80-3) + 2,4,6-triisopropylphenylsulfonyl chloride (6553-96-4) → N2-(2-methylpropanoyl)-2',3',5'-tris-O-(2-methylpropanoyl)-O6-(2''',4''',6'''-triisopropylphenylsulfonyl)guanosine (133324-34-2)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; In chloroform; for 20h;

DOI:10.1021/ja00011a039

Reference yield:

2-Methylpropionic anhydride (97-72-3) → N2-(2-methylpropanoyl)-2',3',5'-tris-O-(2-methylpropanoyl)-O6-(2''',4''',6'''-triisopropylphenylsulfonyl)guanosine (133324-34-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 4-(N,N-dimethylamino)pyridine (DMAP) / pyridine / 24 h / 50 °C

2: 86.5 percent / diisopropylethylamine, 4-(N,N-dimethylamino)pyridine (DMAP) / CHCl₃ / 20 h

With dmap; N-ethyl-N,N-diisopropylamine; In pyridine; chloroform;

DOI:10.1021/ja00011a039

Reference yield:

G (118-00-3) → N2-(2-methylpropanoyl)-2',3',5'-tris-O-(2-methylpropanoyl)-O6-(2''',4''',6'''-triisopropylphenylsulfonyl)guanosine (133324-34-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 4-(N,N-dimethylamino)pyridine (DMAP) / pyridine / 24 h / 50 °C

2: 86.5 percent / diisopropylethylamine, 4-(N,N-dimethylamino)pyridine (DMAP) / CHCl₃ / 20 h

With dmap; N-ethyl-N,N-diisopropylamine; In pyridine; chloroform;

DOI:10.1021/ja00011a039

upstream raw materials:

N²-(2-methylpropanoyl)-2',3',5'-tris-O-(2-methylpropanoyl)guanosine

2,4,6-triisopropylphenylsulfonyl chloride

2-Methylpropionic anhydride

G

Downstream raw materials:

6-18O>guanosine

G

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