ethyl α<(N,N-dimethylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate

Base Information

Chemical Name:ethyl α<(N,N-dimethylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate
CAS No.:138998-47-7
Molecular Formula:C₁₄H₁₃F₄NO₃
Molecular Weight:319.256
Hs Code.:

Synonyms:ethyl α<(N,N-dimethylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate

Suppliers and Price of ethyl α<(N,N-dimethylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
α-[(Dimethylamino)methylene]-2,3,4,5-tetrafluoro-β-oxo-benzenepropanoicAcidEthylEster
5g
$ 3080.00

Total 9 raw suppliers

Chemical Property of ethyl α<(N,N-dimethylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate

Chemical Property:

Boiling Point:381.5±42.0 °C(Predicted)
Density:1.324±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

α-[(Dimethylamino)methylene]-2,3,4,5-tetrafluoro-β-oxo-benzenepropanoicAcidEthylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses α-[(Dimethylamino)methylene]-2,3,4,5-tetrafluoro-β-oxo-benzenepropanoic Acid Ethyl Ester is used in the synthesis of the drug Levofloxacin (L360000), which is a S-(-) form of Ofloxacin (O245750), an antibiotic used against gram-negative organisms.

Technology Process of ethyl α<(N,N-dimethylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate

There total 5 articles about ethyl α<(N,N-dimethylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 94695-50-8
ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 138998-47-7
ethyl α<(N,N-dimethylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate

Guidance literature:: With acetic anhydride; for 0.5h;

Reference yield:

: 924-99-2,1117-37-9,114894-59-6
ethyl 3-(dimethylamino)acrylate

: 94695-48-4
2,3,4,5-tetrafluorobenzoyl chloride

: 138998-47-7
ethyl α<(N,N-dimethylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate

Guidance literature:: With triethylamine; In toluene; at 55 - 60 ℃;
DOI:10.2174/157017811799304322

Reference yield:

: 1201-31-6
2,3,4,5-tetrafluorobenzoic acid

: 138998-47-7
ethyl α<(N,N-dimethylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 3 h / Reflux

2: toluene / 50 °C

With thionyl chloride; In toluene;
DOI:10.1007/s00044-010-9509-9