methyl 2-(4-formyl-3-hydroxyphenyl)-4-methylpentanoate

Base Information

• Chemical Name: methyl 2-(4-formyl-3-hydroxyphenyl)-4-methylpentanoate
• CAS No.: 1257397-45-7
• Molecular Formula: C₁₄H₁₈O₄
• Molecular Weight: 250.295
• Mol file: 1257397-45-7.mol

Synonyms:methyl 2-(4-formyl-3-hydroxyphenyl)-4-methylpentanoate

Chemical Property of methyl 2-(4-formyl-3-hydroxyphenyl)-4-methylpentanoate

Chemical Property:

• Boiling Point: 360.7±27.0 °C(Predicted)
• Density: 1.140±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(4-formyl-3-hydroxyphenyl)-4-methylpentanoate

There total 3 articles about methyl 2-(4-formyl-3-hydroxyphenyl)-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + methyl 2-(3-(benzyloxy)phenyl)-4-methylpent-4-enoate (1257397-44-6) → methyl 2-(4-formyl-3-hydroxyphenyl)-4-methylpentanoate (1257397-45-7)

Guidance literature:

methyl 2-(3-(benzyloxy)phenyl)-4-methylpent-4-enoate; With ethylmagnesium bromide; In tetrahydrofuran; at -1.5 - 3.2 ℃;

formaldehyd; With triethylamine; In tetrahydrofuran; toluene; for 3h; Reflux;

Reference yield:

3-benzyloxy-phenylacetic acid methyl ester (62969-42-0) → methyl 2-(4-formyl-3-hydroxyphenyl)-4-methylpentanoate (1257397-45-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

1.2: -78 - 20 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 3750.38 Torr / Inert atmosphere

3.1: triethylamine; magnesium chloride / acetonitrile / 1.92 h / 40 °C

3.2: 4 h / Reflux

With palladium 10% on activated carbon; hydrogen; triethylamine; magnesium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethyl acetate; acetonitrile;

DOI:10.1016/j.bmcl.2011.10.047

Reference yield:

methyl 2-(3-(benzyloxy)phenyl)-4-methylpent-4-enoate (1257397-43-5) → methyl 2-(4-formyl-3-hydroxyphenyl)-4-methylpentanoate (1257397-45-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 3750.38 Torr / Inert atmosphere

2.1: triethylamine; magnesium chloride / acetonitrile / 1.92 h / 40 °C

2.2: 4 h / Reflux

With palladium 10% on activated carbon; hydrogen; triethylamine; magnesium chloride; In methanol; ethyl acetate; acetonitrile;

DOI:10.1016/j.bmcl.2011.10.047

upstream raw materials:

formaldehyd

methyl 2-(3-(benzyloxy)phenyl)-4-methylpent-4-enoate

3-benzyloxy-phenylacetic acid methyl ester

methyl 2-(3-(benzyloxy)phenyl)-4-methylpent-4-enoate

Refernces

• 1、 -. "CARBOXYLIC ACID-CONTAINING COMPOUNDS, DERIVATIVES THEREOF, AND RELATED METHODS OF USE". Page/Page column 108-109. . Retrieved 2010/12/26.