(2S)-ethyl 2-(7-(4-(allyloxy)-4-methylpieridin-1-yl)-5-methyl-2-(5‘-methyl-2‘-((3-methylpent-4-en-2-yl)oxy)-[1,1‘-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

Base Information

Chemical Name:(2S)-ethyl 2-(7-(4-(allyloxy)-4-methylpieridin-1-yl)-5-methyl-2-(5‘-methyl-2‘-((3-methylpent-4-en-2-yl)oxy)-[1,1‘-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate
CAS No.:1567220-06-7
Molecular Formula:C₄₃H₅₆N₄O₅
Molecular Weight:708.941
Hs Code.:

(2S)-ethyl 2-(7-(4-(allyloxy)-4-methylpieridin-1-yl)-5-methyl-2-(5‘-methyl-2‘-((3-methylpent-4-en-2-yl)oxy)-[1,1‘-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

Synonyms:(2S)-ethyl 2-(7-(4-(allyloxy)-4-methylpieridin-1-yl)-5-methyl-2-(5‘-methyl-2‘-((3-methylpent-4-en-2-yl)oxy)-[1,1‘-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

Suppliers and Price of (2S)-ethyl 2-(7-(4-(allyloxy)-4-methylpieridin-1-yl)-5-methyl-2-(5‘-methyl-2‘-((3-methylpent-4-en-2-yl)oxy)-[1,1‘-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S)-ethyl 2-(7-(4-(allyloxy)-4-methylpieridin-1-yl)-5-methyl-2-(5‘-methyl-2‘-((3-methylpent-4-en-2-yl)oxy)-[1,1‘-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S)-ethyl 2-(7-(4-(allyloxy)-4-methylpieridin-1-yl)-5-methyl-2-(5‘-methyl-2‘-((3-methylpent-4-en-2-yl)oxy)-[1,1‘-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

There total 12 articles about (2S)-ethyl 2-(7-(4-(allyloxy)-4-methylpieridin-1-yl)-5-methyl-2-(5‘-methyl-2‘-((3-methylpent-4-en-2-yl)oxy)-[1,1‘-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.3%

: 1567219-96-8
(S)-ethyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(3-bromophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

: 1567220-02-3
4,4,5,5-tetramethyl-2-(5-methyl-2-((3-methylpent-4-en-2-yl)oxy)phenyl)-1,3,2-dioxaborolane

: 1567220-06-7
(2S)-ethyl 2-(7-(4-(allyloxy)-4-methylpieridin-1-yl)-5-methyl-2-(5‘-methyl-2‘-((3-methylpent-4-en-2-yl)oxy)-[1,1‘-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 5h;

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1567220-06-7
(2S)-ethyl 2-(7-(4-(allyloxy)-4-methylpieridin-1-yl)-5-methyl-2-(5‘-methyl-2‘-((3-methylpent-4-en-2-yl)oxy)-[1,1‘-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: diethyl ether / 2 h / -25 - 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

2.2: 3 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 60 °C

5.1: potassium hexamethylsilazane / tetrahydrofuran / 0.58 h / -78 °C

5.2: 0.5 h / -78 °C

6.1: Dess-Martin periodane / dichloromethane / 1.5 h

7.1: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole / toluene / 4.58 h / -35 - -15 °C

8.1: perchloric acid / dichloromethane / 3 h

9.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 5 h / 90 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; perchloric acid; potassium hexamethylsilazane; sodium hydride; sodium carbonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 406235-30-1
tert-butyl 4-hydroxy-4-methylpiperidine-1-carboxylate

: 1567220-06-7
(2S)-ethyl 2-(7-(4-(allyloxy)-4-methylpieridin-1-yl)-5-methyl-2-(5‘-methyl-2‘-((3-methylpent-4-en-2-yl)oxy)-[1,1‘-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

1.2: 3 h / 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 60 °C

4.1: potassium hexamethylsilazane / tetrahydrofuran / 0.58 h / -78 °C

4.2: 0.5 h / -78 °C

5.1: Dess-Martin periodane / dichloromethane / 1.5 h

6.1: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole / toluene / 4.58 h / -35 - -15 °C

7.1: perchloric acid / dichloromethane / 3 h

8.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 5 h / 90 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; perchloric acid; potassium hexamethylsilazane; sodium hydride; sodium carbonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene;