1-[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]-1-azaspiro[4.5]decane-2,8-dione

Base Information

Chemical Name:1-[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]-1-azaspiro[4.5]decane-2,8-dione
CAS No.:1240017-58-6
Molecular Formula:C₂₀H₂₅NO₃
Molecular Weight:327.423
Hs Code.:

Synonyms:1-[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]-1-azaspiro[4.5]decane-2,8-dione

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Chemical Property of 1-[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]-1-azaspiro[4.5]decane-2,8-dione

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Technology Process of 1-[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]-1-azaspiro[4.5]decane-2,8-dione

There total 13 articles about 1-[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]-1-azaspiro[4.5]decane-2,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1240017-57-5
8,8-dimethoxy-1-[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]-1-azaspiro[4.5]decane-2,4-dione

: 1240017-58-6
1-[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]-1-azaspiro[4.5]decane-2,8-dione

Guidance literature:: 8,8-dimethoxy-1-[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]-1-azaspiro[4.5]decane-2,4-dione; With sodium tetrahydroborate; In methanol; at 20 ℃; for 24h;

With pyridine; trichlorophosphate; at 60 ℃; for 2h;

With magnesium; In methanol; at 20 ℃; Heating;
DOI:10.1016/j.tetlet.2010.05.089

Reference yield:

: C₂₂H₂₉NO₄

: 1240017-58-6
1-[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]-1-azaspiro[4.5]decane-2,8-dione

Guidance literature:: C₂₂H₂₉NO₄; With methanol; magnesium; for 5h; Heating;

With hydrogenchloride; In water; at 0 - 20 ℃; for 2h;
DOI:10.3987/COM-12-S(N)38

Reference yield:

: 4326-36-7
(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

: 1240017-58-6
1-[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]-1-azaspiro[4.5]decane-2,8-dione

Guidance literature:: Multi-step reaction with 12 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: triethylamine; tert-butylmagnesium chloride / tetrahydrofuran / 0 - 20 °C

3.1: sodium tetrahydroborate / methanol / 20 °C

4.1: sodium hydroxide / tetrahydrofuran; water / 20 °C

5.1: potassium thioacyanate / water; ethanol / 24 h / 20 - 60 °C

5.2: 12 h / 80 °C

6.1: hydrogenchloride / methanol; water / 24 h / 20 °C

7.1: methanol / 20 °C

8.1: camphor-10-sulfonic acid; trimethyl orthoformate / 20 °C

9.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere

10.1: sodium tetrahydroborate / methanol / 24 h / 20 °C

11.1: trichlorophosphate; pyridine / 2 h / 60 °C

12.1: methanol; magnesium / 5 h / Heating

12.2: 2 h / 0 - 20 °C

With pyridine; hydrogenchloride; methanol; sodium tetrahydroborate; camphor-10-sulfonic acid; tert-butylmagnesium chloride; potassium thioacyanate; potassium carbonate; magnesium; triethylamine; sodium hydroxide; lithium hexamethyldisilazane; trichlorophosphate; trimethyl orthoformate; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; 7.1: |Ugi Condensation / 9.1: |Dieckmann Condensation;
DOI:10.3987/COM-12-S(N)38