ethyl 3-((2-(4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)ethyl)amino)propanoate

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Chemical Name:ethyl 3-((2-(4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)ethyl)amino)propanoate
CAS No.:1391465-38-5
Molecular Formula:C₂₉H₃₈N₄O₅
Molecular Weight:522.645
Hs Code.:

Synonyms:ethyl 3-((2-(4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)ethyl)amino)propanoate

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Chemical Property of ethyl 3-((2-(4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)ethyl)amino)propanoate

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Technology Process of ethyl 3-((2-(4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)ethyl)amino)propanoate

There total 10 articles about ethyl 3-((2-(4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)ethyl)amino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 1391465-38-5
ethyl 3-((2-(4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)ethyl)amino)propanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide; methanol / water / 4 h / 34 - 70 °C

1.2: 20 °C

2.1: sulfuric acid / methanol / 24 h / Reflux

3.1: bis[1,2-bis(diphenylphosphino)ferrocene]-palladium⁽⁰⁾ / water; tetrahydrofuran / 3 h / 85 °C / Inert atmosphere

4.1: hydrogenchloride; sodium hydroxide / ethanol; water / 0.5 h / 90 °C

5.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 66 h / 5 - 75 °C

6.1: caesium sulfite / N,N-dimethyl-formamide / 0.17 h / 20 °C

6.2: 120 h / 60 °C

7.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 0 - 30 °C

8.1: triethylamine / ethanol / 72 h / 60 °C

With hydrogenchloride; methanol; caesium sulfite; sulfuric acid; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; sodium hydroxide; bis[1,2-bis(diphenylphosphino)ferrocene]-palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 42521-10-8
2-chloro-6-methoxyisonicotinic acid methyl ester

: 1391465-38-5
ethyl 3-((2-(4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)ethyl)amino)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: bis[1,2-bis(diphenylphosphino)ferrocene]-palladium⁽⁰⁾ / water; tetrahydrofuran / 3 h / 85 °C / Inert atmosphere

2.1: hydrogenchloride; sodium hydroxide / ethanol; water / 0.5 h / 90 °C

3.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 66 h / 5 - 75 °C

4.1: caesium sulfite / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 120 h / 60 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 0 - 30 °C

6.1: triethylamine / ethanol / 72 h / 60 °C

With hydrogenchloride; caesium sulfite; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; sodium hydroxide; bis[1,2-bis(diphenylphosphino)ferrocene]-palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;