{2-[(4-bromophenyl)(difluoro)methoxy]-5-fluorophenyl}methanol

Base Information

• Chemical Name: {2-[(4-bromophenyl)(difluoro)methoxy]-5-fluorophenyl}methanol
• CAS No.: 934753-13-6
• Molecular Formula: C₁₄H₁₀BrF₃O₂
• Molecular Weight: 347.131
• Mol file: 934753-13-6.mol

Synonyms:{2-[(4-bromophenyl)(difluoro)methoxy]-5-fluorophenyl}methanol

Chemical Property of {2-[(4-bromophenyl)(difluoro)methoxy]-5-fluorophenyl}methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of {2-[(4-bromophenyl)(difluoro)methoxy]-5-fluorophenyl}methanol

There total 1 articles about {2-[(4-bromophenyl)(difluoro)methoxy]-5-fluorophenyl}methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

1-bromo-4-(bromodifluoromethyl)benzene (2358-32-9) + 5-fluoro-2-hydroxy-benzyl alcohol (2357-33-7) → {2-[(4-bromophenyl)(difluoro)methoxy]-5-fluorophenyl}methanol (934753-13-6)

Guidance literature:

With potassium carbonate; In isopropyl alcohol; for 12h; Reflux;

Reference yield: 85.0%

{2-[(4-bromophenyl)(difluoro)methoxy]-5-fluorophenyl}methanol (934753-13-6) + 4-trifluoromethylphenylboronic acid (128796-39-4) → (2-{Difluoro-[4'-(trifluoromethyl)biphenyl-4-yl]methoxy}-5-fluorophenyl)methanol (934753-14-7)

Guidance literature:

With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; water; for 12h; Inert atmosphere; Reflux;

upstream raw materials:

1-bromo-4-(bromodifluoromethyl)benzene

5-fluoro-2-hydroxy-benzyl alcohol

Downstream raw materials:

(2-{Difluoro-[4'-(trifluoromethyl)biphenyl-4-yl]methoxy}-5-fluorophenyl)methanol