2358-32-9

Basic information

• Product Name: 1-Bromo-4-(bromodifluoromethyl)benzene
• Synonyms: 1-Bromo-4-(bromodifluoromethyl)benzene;ZOTJZUPHVSVCKX-UHFFFAOYSA-N
• CAS NO: 2358-32-9
• Molecular Formula: C₇H₄Br₂F₂
• Molecular Weight: 285.9114664
• Mol File: 2358-32-9.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Bromo-4-(bromodifluoromethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-4-(bromodifluoromethyl)benzene(2358-32-9)
• EPA Substance Registry System: 1-Bromo-4-(bromodifluoromethyl)benzene(2358-32-9)

Safety Data

• Hazardous Substances Data: 2358-32-9(Hazardous Substances Data)

Usage

General Description

1-Bromo-4-(bromodifluoromethyl)benzene is an organic compound with the chemical formula C7H4Br2F2. It is a benzene derivative with two bromine atoms and one difluoromethyl group attached to the benzene ring. 1-Bromo-4-(bromodifluoromethyl)benzene is often used in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of dyes and optical brighteners. It has a variety of industrial applications, including as a reagent in organic chemistry reactions and as a precursor for other organic compounds. 1-Bromo-4-(bromodifluoromethyl)benzene is a colorless to pale yellow liquid with a strong, sharp odor, and it should be handled with care due to its potential for harmful effects if not used properly.

Upstream product

• 589-15-1 1-bromomethyl-4-bromobenzene 
• 589-87-7 1,4-bromoiodobenzene 
• 1004305-97-8 2-(4-bromophenyl)-2,2-difluoroacetic acid ethyl ester 
• 913574-93-3 2-(4-bromophenyl)-2,2-difluoroacetic acid 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 1122-91-4 4-bromo-benzaldehyde 
• 51776-71-7 p-bromo-α,α-difluorotoluene 
• 76092-29-0 1-bromo-4-(tribromomethyl)benzene 

Downstream Products

• 934753-13-6 {2-[(4-bromophenyl)(difluoro)methoxy]-5-fluorophenyl}methanol 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 182676-39-7 5-((4-bromophenyl)difluoromethoxy)-1,2,3-trifluorobenzene 

Relevant articles and documents

Synthesis of ArCF2X and [18F]Ar-CF3via Cleavage of the Trifluoromethylsulfonyl Group

A versatile synthesis of ArCF2X and [18F]Ar-CF3 type compounds from readily available ArCF2SO2CF3 has been developed. Diverse nucleophiles, including weak nucleophiles such as halides (18F-, Cl-, Br-, and I-), RSH, and ROH, could react with ArCF2SO2CF3 efficiently to give the corresponding difluoromethylene products. The control experiments and the Hammett plot indicated that the reaction might proceed through a difluorocarbocation intermediate generated from the steric hindrance-assisted cleavage of the trifluoromethylsulfonyl group.

Iron-Catalyzed Halogen Exchange of Trifluoromethyl Arenes**

The facile production of ArCF2X and ArCX3 from ArCF3 using catalytic iron(III)halides is reported, which constitutes the first iron-catalyzed halogen exchange for non-aromatic C?F bonds. Theoretical calculations suggest direct activation of C?F bonds by iron coordination. ArCX3 and ArCF2X products of the reaction are synthetically valuable due to their diversification potential. In particular, chloro- and bromodifluoromethyl arenes (ArCF2Cl, ArCF2Br respectively) provide access to a myriad of difluoromethyl arene derivatives (ArCF2R). To optimize for mono-halogen exchange, a statistical method called Design of Experiments was used. Optimized parameters were successfully applied to electron rich and electron deficient aromatic substrates, and to the late stage diversification of flufenoxuron, a commercial insecticide. These methods are highly practical, being run at convenient temperatures and using inexpensive common reagents.

Synthesis of trifluoromethyl moieties by late-stage copper (I) mediated nucleophilic fluorination

The nucleophilic fluorination of bromodifluoromethyl derivatives mediated by the complex (PPh3)3CuF is described. Under the reaction conditions, different trifluoroacetates, trifluoroketones, trifluoroarenes and trifluoroacetamides were obtained in good yields.