O⁶-(2,4,6-triisopropylbenzenesulfonyl)-3',5'-O-(di-tert-butylsilanediyl)guanosine

Base Information

• Chemical Name: O⁶-(2,4,6-triisopropylbenzenesulfonyl)-3',5'-O-(di-tert-butylsilanediyl)guanosine
• CAS No.: 1207452-07-0
• Molecular Formula: C₃₃H₅₁N₅O₇SSi
• Molecular Weight: 689.949

Synonyms:O⁶-(2,4,6-triisopropylbenzenesulfonyl)-3',5'-O-(di-tert-butylsilanediyl)guanosine

Chemical Property of O⁶-(2,4,6-triisopropylbenzenesulfonyl)-3',5'-O-(di-tert-butylsilanediyl)guanosine

Chemical Property:

Purity/Quality:

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Technology Process of O⁶-(2,4,6-triisopropylbenzenesulfonyl)-3',5'-O-(di-tert-butylsilanediyl)guanosine

There total 1 articles about O⁶-(2,4,6-triisopropylbenzenesulfonyl)-3',5'-O-(di-tert-butylsilanediyl)guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2,4,6-triisopropylphenylsulfonyl chloride (6553-96-4) + 2-amino-9-((4aR,6R,7R,7aS)-2,2-di-tert-butyl-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxasilin-6-yl)-1,9-dihydro-6H-purin-6-one (126628-29-3) → O6-(2,4,6-triisopropylbenzenesulfonyl)-3',5'-O-(di-tert-butylsilanediyl)guanosine (1207452-07-0)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.bmcl.2009.11.016

Reference yield:

O6-(2,4,6-triisopropylbenzenesulfonyl)-3',5'-O-(di-tert-butylsilanediyl)guanosine (1207452-07-0) + acrylonitrile (107-13-1,25014-41-9) → C36H54N6O7SSi

Guidance literature:

With caesium carbonate; In tert-butyl alcohol; at 20 ℃; for 4h;

DOI:10.1016/j.bmc.2011.12.024

Reference yield:

O6-(2,4,6-triisopropylbenzenesulfonyl)-3',5'-O-(di-tert-butylsilanediyl)guanosine (1207452-07-0) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → N2-dimethylaminomethylene-O6-(2,4,6-triisopropylbenzenesulfonyl)-3',5'-O-di-tert-butylsilanediylguanosine (1207451-99-7)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 14.5h; Inert atmosphere;

DOI:10.1016/j.bmcl.2009.11.016

upstream raw materials:

2,4,6-triisopropylphenylsulfonyl chloride

2-amino-9-((4aR,6R,7R,7aS)-2,2-di-tert-butyl-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxasilin-6-yl)-1,9-dihydro-6H-purin-6-one

Downstream raw materials:

N₂-dimethylaminomethylene-O₆-(2,4,6-triisopropylbenzenesulfonyl)-3',5'-O-di-tert-butylsilanediylguanosine

N₂-isobutyryl-2'-O-(N,N'-di-Boc-guanidinopropyl)-5'-O-(4,4'-dimethoxytrityl)-guanosine

N₂-isobutyryl-2'-O-(N,N'-di-Boc-N'-isobutyryl-guanidinopropyl)-5'-O-(4,4'-dimethoxytrityl)-guanosine

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