thioacetic acid S-(3-{4-[bis-[4-(3-acetylsulfanylmethyl-phenylethynyl)-phenyl]-(4-iodo-phenyl)-silanyl]-phenylethynyl}-benzyl) ester

Base Information

Chemical Name:thioacetic acid S-(3-{4-[bis-[4-(3-acetylsulfanylmethyl-phenylethynyl)-phenyl]-(4-iodo-phenyl)-silanyl]-phenylethynyl}-benzyl) ester
CAS No.:568592-02-9
Molecular Formula:C₅₇H₄₃IO₃S₃Si
Molecular Weight:1027.15
Hs Code.:

thioacetic acid <i>S</i>-(3-{4-[bis-[4-(3-acetylsulfanylmethyl-phenylethynyl)-phenyl]-(4-iodo-phenyl)-silanyl]-phenylethynyl}-benzyl) ester

Synonyms:thioacetic acid S-(3-{4-[bis-[4-(3-acetylsulfanylmethyl-phenylethynyl)-phenyl]-(4-iodo-phenyl)-silanyl]-phenylethynyl}-benzyl) ester

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Chemical Property of thioacetic acid S-(3-{4-[bis-[4-(3-acetylsulfanylmethyl-phenylethynyl)-phenyl]-(4-iodo-phenyl)-silanyl]-phenylethynyl}-benzyl) ester

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Technology Process of thioacetic acid S-(3-{4-[bis-[4-(3-acetylsulfanylmethyl-phenylethynyl)-phenyl]-(4-iodo-phenyl)-silanyl]-phenylethynyl}-benzyl) ester

There total 8 articles about thioacetic acid S-(3-{4-[bis-[4-(3-acetylsulfanylmethyl-phenylethynyl)-phenyl]-(4-iodo-phenyl)-silanyl]-phenylethynyl}-benzyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 507-09-5
tiolacetic acid

: 568592-01-8
tris{4-[3-(hydroxymethyl)phenylethynyl]phenyl}-4'-iodophenylsilane

: 568592-02-9
thioacetic acid S-(3-{4-[bis-[4-(3-acetylsulfanylmethyl-phenylethynyl)-phenyl]-(4-iodo-phenyl)-silanyl]-phenylethynyl}-benzyl) ester

Guidance literature:: With di-isopropyl azodicarboxylate; phosphan; In tetrahydrofuran; at 20 ℃; for 4.5h;
DOI:10.1021/jo034169h

Reference yield:

: 57455-06-8
3-iodobenzylalcohol

: 568592-02-9
thioacetic acid S-(3-{4-[bis-[4-(3-acetylsulfanylmethyl-phenylethynyl)-phenyl]-(4-iodo-phenyl)-silanyl]-phenylethynyl}-benzyl) ester

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / imidazole / CH₂Cl₂ / 2 h / 20 °C

2: 98 percent / Pd(PPh₃)2Cl₂; CuI; Et₃N / tetrahydrofuran / 20 °C

3: 95 percent / K₂CO₃ / methanol; tetrahydrofuran / 20 °C

4: 95 percent / i-Pr₂NEt; CuI; PPh₃ / Pd(dba)2 / tetrahydrofuran / 48 h / 20 °C

5: 88 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C

6: 90 percent / AcOH; TBAF / tetrahydrofuran / 28 h / 20 °C

7: 70 percent / Ph₃; diisopropylazodicarboxylate / tetrahydrofuran / 4.5 h / 20 °C

With 1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; phosphan; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexane; dichloromethane; 7: Mitsunobu reaction;
DOI:10.1021/jo034169h

Reference yield:

: 568591-98-0
tert-butyl(3-ethynylbenzyloxy)dimethylsilane

: 568592-02-9
thioacetic acid S-(3-{4-[bis-[4-(3-acetylsulfanylmethyl-phenylethynyl)-phenyl]-(4-iodo-phenyl)-silanyl]-phenylethynyl}-benzyl) ester

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / i-Pr₂NEt; CuI; PPh₃ / Pd(dba)2 / tetrahydrofuran / 48 h / 20 °C

2: 88 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C

3: 90 percent / AcOH; TBAF / tetrahydrofuran / 28 h / 20 °C

4: 70 percent / Ph₃; diisopropylazodicarboxylate / tetrahydrofuran / 4.5 h / 20 °C

With copper(l) iodide; n-butyllithium; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; phosphan; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; hexane; 4: Mitsunobu reaction;
DOI:10.1021/jo034169h