β-trimethylsilylethyl 3-benzylthio-7-(R)-t-butyldimethylsiloxyethyl-1-dethia-2-thia-3-cephemcarboxylate

Base Information

Chemical Name:β-trimethylsilylethyl 3-benzylthio-7-(R)-t-butyldimethylsiloxyethyl-1-dethia-2-thia-3-cephemcarboxylate
CAS No.:141422-82-4
Molecular Formula:C₂₇H₄₃NO₄S₂Si₂
Molecular Weight:565.946
Hs Code.:

Synonyms:β-trimethylsilylethyl 3-benzylthio-7-(R)-t-butyldimethylsiloxyethyl-1-dethia-2-thia-3-cephemcarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of β-trimethylsilylethyl 3-benzylthio-7-(R)-t-butyldimethylsiloxyethyl-1-dethia-2-thia-3-cephemcarboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of β-trimethylsilylethyl 3-benzylthio-7-(R)-t-butyldimethylsiloxyethyl-1-dethia-2-thia-3-cephemcarboxylate

There total 3 articles about β-trimethylsilylethyl 3-benzylthio-7-(R)-t-butyldimethylsiloxyethyl-1-dethia-2-thia-3-cephemcarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79414-13-4
trimethylsilylethyl bromoacetate

: 141422-82-4
β-trimethylsilylethyl 3-benzylthio-7-(R)-t-butyldimethylsiloxyethyl-1-dethia-2-thia-3-cephemcarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / NaH / dimethylformamide / 18 h / 25 °C

2: 1.) LDA, 2.) CS₂ / 1.) THF, -78 deg C, 15 min, 2.) THF, from -78 deg C to RT, 18 h

3: 1.) NaH / 1.) THF, 0 deg C, 2.) THF, from 0 to 25 deg C, 30 min

With carbon disulfide; sodium hydride; lithium diisopropyl amide; In N,N-dimethyl-formamide;

Reference yield:

: 84362-41-4
(3S,4S)-3-<(R)-1-(t-butyldimethylsilyloxy)ethyl>-4-(p-tolylsulfonyloxymethyl)-2-azetidinone

: 141422-82-4
β-trimethylsilylethyl 3-benzylthio-7-(R)-t-butyldimethylsiloxyethyl-1-dethia-2-thia-3-cephemcarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / NaH / dimethylformamide / 18 h / 25 °C

2: 1.) LDA, 2.) CS₂ / 1.) THF, -78 deg C, 15 min, 2.) THF, from -78 deg C to RT, 18 h

3: 1.) NaH / 1.) THF, 0 deg C, 2.) THF, from 0 to 25 deg C, 30 min

With carbon disulfide; sodium hydride; lithium diisopropyl amide; In N,N-dimethyl-formamide;

Reference yield:

: 141422-75-5
[(3S,4S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-(toluene-4-sulfonyloxymethyl)-azetidin-1-yl]-acetic acid 2-trimethylsilanyl-ethyl ester

: 141422-82-4
β-trimethylsilylethyl 3-benzylthio-7-(R)-t-butyldimethylsiloxyethyl-1-dethia-2-thia-3-cephemcarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA, 2.) CS₂ / 1.) THF, -78 deg C, 15 min, 2.) THF, from -78 deg C to RT, 18 h

2: 1.) NaH / 1.) THF, 0 deg C, 2.) THF, from 0 to 25 deg C, 30 min

With carbon disulfide; sodium hydride; lithium diisopropyl amide;