[(3S,4S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-(toluene-4-sulfonyloxymethyl)-azetidin-1-yl]-acetic acid 2-trimethylsilanyl-ethyl ester

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Chemical Name:[(3S,4S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-(toluene-4-sulfonyloxymethyl)-azetidin-1-yl]-acetic acid 2-trimethylsilanyl-ethyl ester
CAS No.:141422-75-5
Molecular Formula:C₂₆H₄₅NO₇SSi₂
Molecular Weight:571.883
Hs Code.:

[(3S,4S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-(toluene-4-sulfonyloxymethyl)-azetidin-1-yl]-acetic acid 2-trimethylsilanyl-ethyl ester

Synonyms:[(3S,4S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-(toluene-4-sulfonyloxymethyl)-azetidin-1-yl]-acetic acid 2-trimethylsilanyl-ethyl ester

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Chemical Property of [(3S,4S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-(toluene-4-sulfonyloxymethyl)-azetidin-1-yl]-acetic acid 2-trimethylsilanyl-ethyl ester

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Technology Process of [(3S,4S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-(toluene-4-sulfonyloxymethyl)-azetidin-1-yl]-acetic acid 2-trimethylsilanyl-ethyl ester

There total 1 articles about [(3S,4S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-(toluene-4-sulfonyloxymethyl)-azetidin-1-yl]-acetic acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 79414-13-4
trimethylsilylethyl bromoacetate

: 84362-41-4
(3S,4S)-3-<(R)-1-(t-butyldimethylsilyloxy)ethyl>-4-(p-tolylsulfonyloxymethyl)-2-azetidinone

: 141422-75-5
[(3S,4S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-(toluene-4-sulfonyloxymethyl)-azetidin-1-yl]-acetic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 25 ℃; for 18h;

Reference yield:

: 141422-75-5
[(3S,4S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-(toluene-4-sulfonyloxymethyl)-azetidin-1-yl]-acetic acid 2-trimethylsilanyl-ethyl ester

: 141422-87-9
(+)-3-benzylthio-7-(R)-hydroxyethyl-1-dethia-2-thia-3-cephemcarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA, 2.) CS₂ / 1.) THF, -78 deg C, 15 min, 2.) THF, from -78 deg C to RT, 18 h

2: 1.) NaH / 1.) THF, 0 deg C, 2.) THF, from 0 to 25 deg C, 30 min

3: 21 percent / tetrabutylammonium fluoride (TBAF) / tetrahydrofuran / 18 h / 25 °C

With carbon disulfide; tetrabutyl ammonium fluoride; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran;

Reference yield:

: 141422-75-5
[(3S,4S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-(toluene-4-sulfonyloxymethyl)-azetidin-1-yl]-acetic acid 2-trimethylsilanyl-ethyl ester

: 141422-82-4
β-trimethylsilylethyl 3-benzylthio-7-(R)-t-butyldimethylsiloxyethyl-1-dethia-2-thia-3-cephemcarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA, 2.) CS₂ / 1.) THF, -78 deg C, 15 min, 2.) THF, from -78 deg C to RT, 18 h

2: 1.) NaH / 1.) THF, 0 deg C, 2.) THF, from 0 to 25 deg C, 30 min

With carbon disulfide; sodium hydride; lithium diisopropyl amide;