(+)-3-benzylthio-7-(R)-hydroxyethyl-1-dethia-2-thia-3-cephemcarboxylic acid

Base Information

Chemical Name:(+)-3-benzylthio-7-(R)-hydroxyethyl-1-dethia-2-thia-3-cephemcarboxylic acid
CAS No.:141422-87-9
Molecular Formula:C₁₆H₁₇NO₄S₂
Molecular Weight:351.447
Hs Code.:

Synonyms:(+)-3-benzylthio-7-(R)-hydroxyethyl-1-dethia-2-thia-3-cephemcarboxylic acid

Suppliers and Price of (+)-3-benzylthio-7-(R)-hydroxyethyl-1-dethia-2-thia-3-cephemcarboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-3-benzylthio-7-(R)-hydroxyethyl-1-dethia-2-thia-3-cephemcarboxylic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (+)-3-benzylthio-7-(R)-hydroxyethyl-1-dethia-2-thia-3-cephemcarboxylic acid

There total 4 articles about (+)-3-benzylthio-7-(R)-hydroxyethyl-1-dethia-2-thia-3-cephemcarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 141422-82-4
β-trimethylsilylethyl 3-benzylthio-7-(R)-t-butyldimethylsiloxyethyl-1-dethia-2-thia-3-cephemcarboxylate

: 141422-87-9
(+)-3-benzylthio-7-(R)-hydroxyethyl-1-dethia-2-thia-3-cephemcarboxylic acid

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 18h;

Reference yield:

: 84362-41-4
(3S,4S)-3-<(R)-1-(t-butyldimethylsilyloxy)ethyl>-4-(p-tolylsulfonyloxymethyl)-2-azetidinone

: 141422-87-9
(+)-3-benzylthio-7-(R)-hydroxyethyl-1-dethia-2-thia-3-cephemcarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / NaH / dimethylformamide / 18 h / 25 °C

2: 1.) LDA, 2.) CS₂ / 1.) THF, -78 deg C, 15 min, 2.) THF, from -78 deg C to RT, 18 h

3: 1.) NaH / 1.) THF, 0 deg C, 2.) THF, from 0 to 25 deg C, 30 min

4: 21 percent / tetrabutylammonium fluoride (TBAF) / tetrahydrofuran / 18 h / 25 °C

With carbon disulfide; tetrabutyl ammonium fluoride; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 141422-83-5
(6S,7S)-7-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-mercapto-8-oxo-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 2-trimethylsilanyl-ethyl ester

: 141422-87-9
(+)-3-benzylthio-7-(R)-hydroxyethyl-1-dethia-2-thia-3-cephemcarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) THF, 0 deg C, 2.) THF, from 0 to 25 deg C, 30 min

2: 21 percent / tetrabutylammonium fluoride (TBAF) / tetrahydrofuran / 18 h / 25 °C

With tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran;