4-(N-(cyclohexylmethyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid

Base Information

Chemical Name:4-(N-(cyclohexylmethyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid
CAS No.:1331747-43-3
Molecular Formula:C₂₄H₃₀N₂O₆S
Molecular Weight:474.578
Hs Code.:

Synonyms:4-(N-(cyclohexylmethyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid

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Chemical Property of 4-(N-(cyclohexylmethyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid

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Technology Process of 4-(N-(cyclohexylmethyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid

There total 7 articles about 4-(N-(cyclohexylmethyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1331747-38-6
benzyl 2-(benzyloxy)-4-(N-(cyclohexylmethyl)-2-(N,4-dimethylphenyl-sulfonamido)acetamido)benzoate

: 1331747-43-3
4-(N-(cyclohexylmethyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; for 3h;

Reference yield:

: 28126-01-4
methyl 2-(N,4-dimethylphenylsulfonam ido)acetate

: 1331747-43-3
4-(N-(cyclohexylmethyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 1 h / 20 °C / Inert atmosphere

2: dichlorotriphenylphosphorane / chloroform / 12 h / 60 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 20 °C

With lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; dichlorotriphenylphosphorane; In tetrahydrofuran; methanol; chloroform;
DOI:10.1002/cmdc.201100194

Reference yield:

: 2645-02-5
methyl tosylglycinate

: 1331747-43-3
4-(N-(cyclohexylmethyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

2: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 1 h / 20 °C / Inert atmosphere

3: dichlorotriphenylphosphorane / chloroform / 12 h / 60 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 20 °C

With lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; caesium carbonate; dichlorotriphenylphosphorane; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201100194