Technology Process of S-4-(((tert-butoxycarbonyl)amino)methyl)benzyl ethanethioate
There total 4 articles about S-4-(((tert-butoxycarbonyl)amino)methyl)benzyl ethanethioate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tiolacetic acid; tert-butyl 4-hydroxymethylbenzylcarbamate;
With
triphenylphosphine;
In
tetrahydrofuran;
Inert atmosphere;
Cooling with ice;
With
di-isopropyl azodicarboxylate;
In
tetrahydrofuran;
Inert atmosphere;
DOI:10.1002/anie.201106527
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydroxide / tert-butyl alcohol / 0 - 20 °C
2.1: triphenylphosphine / tetrahydrofuran / Inert atmosphere; Cooling with ice
2.2: Inert atmosphere
With
triphenylphosphine; sodium hydroxide;
In
tetrahydrofuran; tert-butyl alcohol;
2.1: Mitsunobu reaction / 2.2: Mitsunobu reaction;
DOI:10.1002/anie.201106527
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Reflux
2.1: sodium hydroxide / tert-butyl alcohol / 0 - 20 °C
3.1: triphenylphosphine / tetrahydrofuran / Inert atmosphere; Cooling with ice
3.2: Inert atmosphere
With
lithium aluminium tetrahydride; triphenylphosphine; sodium hydroxide;
In
tetrahydrofuran; tert-butyl alcohol;
3.1: Mitsunobu reaction / 3.2: Mitsunobu reaction;
DOI:10.1002/anie.201106527
