2-bromoacetic acid 1-trityloxymethylallyl ester

Base Information

• Chemical Name: 2-bromoacetic acid 1-trityloxymethylallyl ester
• CAS No.: 1206535-36-5
• Molecular Formula: C₂₅H₂₃BrO₃
• Molecular Weight: 451.36
• Mol file: 1206535-36-5.mol

Synonyms:2-bromoacetic acid 1-trityloxymethylallyl ester

Chemical Property of 2-bromoacetic acid 1-trityloxymethylallyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-bromoacetic acid 1-trityloxymethylallyl ester

There total 1 articles about 2-bromoacetic acid 1-trityloxymethylallyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

1-triphenylmethoxy-but-3-en-2-ol (89543-83-9) + bromoacetic acid (79-08-3) → 2-bromoacetic acid 1-trityloxymethylallyl ester (1206535-36-5)

Guidance literature:

bromoacetic acid; With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 20 ℃; for 0.25h; Inert atmosphere;

1-triphenylmethoxy-but-3-en-2-ol; With dmap; In tetrahydrofuran; Inert atmosphere;

DOI:10.1002/anie.200905167

Reference yield: 83.0%

2-bromoacetic acid 1-trityloxymethylallyl ester (1206535-36-5) → rac-(4R,5R)-4-methyl-5-trityloxymethyltetrahydro-2-furanol

Guidance literature:

2-bromoacetic acid 1-trityloxymethylallyl ester; With diisobutylaluminium hydride; In toluene; at -78 ℃; Inert atmosphere;

With triethyl borane; tri-n-butyl-tin hydride; In hexane; toluene; at -78 ℃; Inert atmosphere;

With sodium fluoride; In hexane; water; toluene; for 0.25h; stereoselective reaction;

DOI:10.1002/anie.200905167

Reference yield: 62.0%

2-bromoacetic acid 1-trityloxymethylallyl ester (1206535-36-5) → rac-(4R,5R)-4-methyl-5-trityloxymethyltetrahydro-2-furanone

Guidance literature:

2-bromoacetic acid 1-trityloxymethylallyl ester; With diisobutylaluminium hydride; In toluene; at -78 ℃; Inert atmosphere;

With triethyl borane; tri-n-butyl-tin hydride; In toluene; at -70 ℃; Inert atmosphere;

With benzaldehyde; In toluene; at -70 - 25 ℃; for 4h; optical yield given as %de; Inert atmosphere;

DOI:10.1002/asia.201200212

upstream raw materials:

1-triphenylmethoxy-but-3-en-2-ol

bromoacetic acid