5-(benzyloxy)-N-(3,4-dimethoxybenzyl)-4-fluoro-2-(tetrahydro-2H-pyran-4-ylamino)benzamide

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Chemical Name:5-(benzyloxy)-N-(3,4-dimethoxybenzyl)-4-fluoro-2-(tetrahydro-2H-pyran-4-ylamino)benzamide
CAS No.:1251702-43-8
Molecular Formula:C₂₈H₃₁FN₂O₅
Molecular Weight:494.563
Hs Code.:

Synonyms:5-(benzyloxy)-N-(3,4-dimethoxybenzyl)-4-fluoro-2-(tetrahydro-2H-pyran-4-ylamino)benzamide

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Chemical Property of 5-(benzyloxy)-N-(3,4-dimethoxybenzyl)-4-fluoro-2-(tetrahydro-2H-pyran-4-ylamino)benzamide

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Technology Process of 5-(benzyloxy)-N-(3,4-dimethoxybenzyl)-4-fluoro-2-(tetrahydro-2H-pyran-4-ylamino)benzamide

There total 6 articles about 5-(benzyloxy)-N-(3,4-dimethoxybenzyl)-4-fluoro-2-(tetrahydro-2H-pyran-4-ylamino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1251702-42-7
5-(benzyloxy)-4-fluoro-2-(tetrahydro-2H-pyran-4-ylamino)benzoic acid

: 5763-61-1
3,4-dimethoxybenzylamine

: 1251702-43-8
5-(benzyloxy)-N-(3,4-dimethoxybenzyl)-4-fluoro-2-(tetrahydro-2H-pyran-4-ylamino)benzamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 1251702-43-8
5-(benzyloxy)-N-(3,4-dimethoxybenzyl)-4-fluoro-2-(tetrahydro-2H-pyran-4-ylamino)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 0.17 h / 20 °C

1.2: 1 h / 20 °C

2.1: ammonium chloride; iron / isopropyl alcohol; water; tetrahydrofuran / 6 h / 90 °C

3.1: sodium sulfate / acetic acid / 20 °C

3.2: 3 h / 20 °C

4.1: potassium hydroxide; water / isopropyl alcohol / 0.33 h / 130 °C / Microwave irradiation

5.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C

With water; iron; ammonium chloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sodium sulfate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; water; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1214387-06-0
4,5-difluoro-2-nitrobenzoic acid ethyl ester

: 1251702-43-8
5-(benzyloxy)-N-(3,4-dimethoxybenzyl)-4-fluoro-2-(tetrahydro-2H-pyran-4-ylamino)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 0.17 h / 20 °C

1.2: 1 h / 20 °C

2.1: ammonium chloride; iron / isopropyl alcohol; water; tetrahydrofuran / 6 h / 90 °C

3.1: sodium sulfate / acetic acid / 20 °C

3.2: 3 h / 20 °C

4.1: potassium hydroxide; water / isopropyl alcohol / 0.33 h / 130 °C / Microwave irradiation

5.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C

With water; iron; ammonium chloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sodium sulfate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; water; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;