Technology Process of (2S)-2-benzhydryl-3,6-dihydro-2H-pyran
There total 12 articles about (2S)-2-benzhydryl-3,6-dihydro-2H-pyran which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
benzene;
for 20h;
Heating;
DOI:10.1021/jm049021k
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: dihydrogen peroxide / water / 20 °C / Inert atmosphere
2.1: 80 - 180 °C / Neat (no solvent); Pyrolysis under reduced pressure
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Cooling with ice; Inert atmosphere
4.1: (R,R)-Jacobsen catalyst; water / 72 h / 20 °C / Cooling with ice; Inert atmosphere
5.1: copper(l) iodide / tetrahydrofuran / -78 - 20 °C / Inert atmosphere
5.2: 0 °C / Inert atmosphere
6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C / Inert atmosphere
6.2: 0 - 20 °C / Inert atmosphere
7.1: Grubbs catalyst first generation / benzene / 2 h / Reflux; Inert atmosphere
With
Grubbs catalyst first generation; copper(l) iodide; (R,R)-Jacobsen catalyst; water; dihydrogen peroxide; sodium hydride; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; benzene;
DOI:10.1016/j.tetasy.2011.05.012
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 93 percent / H2O; Jacobsen's catalyst / 72 h / 20 °C
2.1: 70 percent / CuI / tetrahydrofuran / 2 h / -78 - 20 °C
3.1: NaH / dimethylformamide / 1 h / 0 - 20 °C
3.2: 85 percent / dimethylformamide / 20 °C
4.1: 88 percent / Grubb's catalyst / benzene / 20 h / Heating
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; copper(l) iodide; Jacobsen's catalyst; water; sodium hydride;
In
tetrahydrofuran; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm049021k