HEXADIMETHRINE BROMIDE

Base Information

• Chemical Name: HEXADIMETHRINE BROMIDE
• CAS No.: 28728-55-4
• Molecular Formula: 2Br*C₃₉H₈₄N₂
• Molecular Weight: 740.917
• Mol file: 28728-55-4.mol

Synonyms:Poly[(dimethyliminio)-1,3-propanediyl(dimethyliminio)-1,6-hexanediyldibromide] (9CI);Poly[(dimethyliminio)trimethylene(dimethyliminio)hexamethylene dibromide](8CI); 1,3-Dibromopropane-N,N,N',N'-tetramethyl-1,6-hexanediamine copolymer,SRU; 1,3-Dibromopropane-N,N,N',N'-tetramethylhexamethylenediamine polymer, SRU;1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide; 3,6-Ionene; 6,3-Ionene;6,3-Ionene bromide; Biobrene Plus; COP 1; COP 1 (onium compound);Hexadimethrine bromide; Ionene-6,3;Poly(N,N,N',N'-tetramethyl-N-trimethylene-N'-hexamethylenediammonium dibromide);Poly[(dimethyliminio)-1,6-hexanediyl(dimethyliminio)-1,3-propanediyldibromide]; Polybrene

Chemical Property of HEXADIMETHRINE BROMIDE

Chemical Property:

• Appearance/Colour: WHITE TO OFF-WHITE POWDER
• Vapor Pressure: 0.202mmHg at 25°C
• Boiling Point: 209.5 °C at 760 mmHg
• Flash Point: 73.9 °C
• PSA: 0.00000
• Density: g/cm³
• LogP: -11.24780
• Storage Temp.: 2-8°C
• Solubility.: H2O: 0.1 g/mL, clear to slightly hazy, colorless to faintly

Purity/Quality:

98%,99%, ^*data from raw suppliers

Hexadimethrine bromide ≥94% (titration) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Hexadimethrine bromide can be used to transfect mammalian cells with DNA. It can be used to increase the efficiency of lipofection transfections.Hexadimethrine bromide has been used for lentivirus infection in cells. It has been used for infection of cells with retroviral supernatant. Antiheparin agent. A 3mg quantity has been found to enhance peptide degradation in automated sequential analysis. Used as a protein/peptide carrier for protein sequencing.

Technology Process of HEXADIMETHRINE BROMIDE

There total 17 articles about HEXADIMETHRINE BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N,N-dimethylaminododecane (112-18-5,83855-86-1) + 1,3-dibromo-propane (109-64-8) → dodecyl[3-[dodecyl(dimethyl)ammonio]propyl]dimethylammonium dibromide (21948-96-9,28728-55-4)

Guidance literature:

In ethanol; for 24h; Reflux;

DOI:10.5012/bkcs.2010.31.8.2289

Reference yield: 93.0%

N-(3-dimethylaminopropyl)-N,N-dimethyl-6- (pyren-6-yl)hexan-1-ammonium bromide + 1-dodecylbromide (143-15-7) → (N1-dodecyl-N1,N1,N3,N3-tetramethyl-N3-(6-pyren-6yl)-hexyl)propane-1,3-diammonium dibromide (28728-55-4)

Guidance literature:

In acetonitrile; for 48h; Reflux;

DOI:10.1021/acs.langmuir.1c00847

Reference yield: 74.3%

N,N,N'N'-tetramethyl-1,3-propanediamine (110-95-2) + 1-dodecylbromide (143-15-7) → dodecyl[3-[dodecyl(dimethyl)ammonio]propyl]dimethylammonium dibromide (21948-96-9,28728-55-4)

Guidance literature:

In acetonitrile; at 20 ℃; Reflux;

DOI:10.1016/j.chemphyslip.2009.04.004

upstream raw materials:

N,N,N'N'-tetramethyl-1,3-propanediamine

1-dodecylbromide

N,N-dimethylaminododecane

1,3-dibromo-propane

Refernces

• 1、 Zapilko, Clemens,Liang, Yucang,Nerdal, Willy,Anwander, Reiner. "A general strategy for the rational design of size-selective mesoporous catalysts". . p. 3169 - 3176. Retrieved 2007.
• 2、 Han, Lu,Sakamoto, Yasuhiro,Terasaki, Osamu,Li, Yongsheng,Che, Shunai. "Synthesis of carboxylic group functionalized mesoporous silicas (CFMSs) with various structures". . p. 1216 - 1221. Retrieved 2007.
• 3、 Hattori, Norikatsu,Yoshino, Akihiro,Okabayashi, Hirofumi,O'Connor, Charmian J.. "Conformational analysis of (Phenylenedimethylene)bis(n-octylammonium)dibromides in aqueous solution. Conformational change upon micellization". . p. 8965 - 8973. Retrieved 1998.
• 4、 Verma, Santosh Kumar,Ghritlahre, Bhupendra Kumar,Ghosh, Kallol K,Verma, Rameshwari,Verma, Shekhar,Zhao, Xiujian. "Influence of Amine-Based Cationic Gemini Surfactants on Catalytic Activity of α-Chymotrypsin". . p. 779 - 784. Retrieved 2016/11/02.