110-95-2

Basic information

• Product Name: Tetramethyl-1,3-diaminopropane
• Synonyms: (CH3)2N(CH2)3N(CH3)2;3-Propanediamine,N,N,N’,N’-tetramethyl-1;bis((dimethylamino)methyl)methane;Bis[(dimethylamino)methyl]methane;n,n,n’,n’-tetramethyl-3-propanediamine;Propane-1,3-diamine, N,N,N',N'-tetramethyl-;tetramethyl-1,3-propanediamine;Tetramethyltrimethylenediamine
• CAS NO: 110-95-2
• Molecular Formula: C₇H₁₈N₂
• Molecular Weight: 130.23
• EINECS: 203-818-8
• Product Categories: Bioactive Small Molecules;Building Blocks;Cell Biology;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;Polyamines;T;is a highly active, pure liquid tertiary amine that is suitable for use as a blowing catalyst in a number of rigid polyurethane foam applications;fine chemical;fine chemicals
• Mol File: 110-95-2.mol
• Article Data: 9

Chemical Properties

• Melting Point: 28.9°C (estimate)
• Boiling Point: 145-146 °C(lit.)
• Flash Point: 89 °F
• Appearance: Clear colorless to light yellow/Liquid
• Density: 0.779 g/mL at 25 °C(lit.)
• Vapor Pressure: 760 mm Hg ( 145 °C)
• Refractive Index: n20/D 1.4234(lit.)
• Storage Temp.: Flammables area
• PKA: 9.88±0.28(Predicted)
• Explosive Limit: 2.9-22.5%(V)
• Stability: Stable. Flammable. Incompatible with strong oxidizing agents, acids, acid chlorides, permanganates, carbon dioxide, nitrates, pe
• BRN: 1734176
• CAS DataBase Reference: Tetramethyl-1,3-diaminopropane(CAS DataBase Reference)
• NIST Chemistry Reference: Tetramethyl-1,3-diaminopropane(110-95-2)
• EPA Substance Registry System: Tetramethyl-1,3-diaminopropane(110-95-2)

Safety Data

• Hazard Codes: T,Xi
• Statements: 10-22-24-34
• Safety Statements: 16-26-36/37/39-45-24/25
• RIDADR: UN 2734 8/PG 2
• WGK Germany: 2
• RTECS: TX8400000
• F: 10-34
• TSCA: Yes
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 110-95-2(Hazardous Substances Data)

Usage

Chemical Properties

colourless liquid

General Description

N,N,N′,N′-Tetramethyl-1,3-propanediamine is an acyclic tertiary amine. It shows the ability to absorb CO2 when dissolved in aqueous solution. N,N,N′,N′-Tetramethyl-1,3-propanediamine (TMPDA) may be used: As a catalyst for the Baylis-Hillman reaction of cycloalkenones. In the preparation of homodimeric asymmetric monomethine cyanine dyes during the bisquaternization process. As a ligand (L) for the preparation of dinuclear μ-carbonato-dicopper(II) species.

Flammability and Explosibility

Flammable

Upstream product

• 506-59-2 N,N-dimethylammonium chloride 
• 124-40-3 dimethyl amine 
• 1738-25-6 3-dimethylaminopropiononitrile 
• 123147-90-0 dimethyl(N,N,N',N'-tetramethyl-1,3-propanediamine)palladium(II) 
• 123147-91-1 dimethyl-d6-(N,N,N',N'-tetramethyl-1,3-propanediamine)palladium(II) 
• 5350-67-4 α-(dimethylamino)-propionitrile 
• 17471-59-9 tetra-N-methyl-ξ-propenediyldiamine 
• 110-82-7 cyclohexane 
• 50-00-0 formaldehyd 
• 109-76-2 Trimethylenediamine 
• 4605-14-5 N,N'-bis-(3-aminopropyl)-1,3-propanediamine 
• 1611-78-5 1,3-bis-dimethylaminotrimethinium perchlorate 
• 42779-37-3 1,3-bis(dimethylamino)-propane-2-thiol 
• 17268-47-2 3-(N,N-dimethylamino)-N',N'-dimethylpropionamide 

Downstream Products

• 28728-55-4 1,3-propanediyl-bis(N,N-dimethyl-N-oleylammonium) dibromide 
• 39515-41-8 fenpropathrin 
• 926036-44-4 N-(2-((3-(dimethylamino)propyl)(methyl)amino)-5-(trifluoromethyl)phenyl)-2-fluoro-5-iodobenzamide 
• 861881-24-5 N¹-(3-(dimethylamino)propyl)-N¹-methyl-4-(trifluoromethyl)benzene-1,2-diamine 
• 926277-94-3 N-(3-(dimethylamino)propyl)-N-methyl-2-nitro-4-(trifluoromethyl)benzenamine 
• 28728-55-4 propanediyl-α,ω-bis(octyldimethylammonium bromide) 

Relevant articles and documents

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Fragmentation During the Formic Acid/Formaldehyde (Eschweiler-Clarke) Methylation of Polyamines

Eschweiler-Clarke methylations of both acyclic and cyclic polyamines can lead to methylation products of fragments of the original polyamine; thus 1,5,9,13-tetra-azatridecane yields 1,1,3,3-tetramethylpropanediamine exclusively and 1,5,9-triazacyclododecane gives 45 percent 1,5,9-trimethyl-1,5,9-triazacyclododecane and 45 percent 2,6,10-trimethyl-2,6,10-triazaundecane.

REDUCTIVE PREPARATION OF TERTIARY DIMETHYLAMINES FROM NITRILES

This disclosure describes a low temperature process for the preparation of dimethyl amines from nitriles via reductive amination. In some embodiments, the process proceeds under mild conditions with aqeuous dimethylamine and show an unexpected rate acceleration by the inclusion of an acid addition salt of the dimethylamine.

Low pressure process for manufacture of 3-dimethylaminopropylamine (DMAPA)

An improved process for the production of 3-dimethylaminopropylamine in high purity from N,N-dimethylaminopropionitrile utilizing a low pressure hydrogenation process is described. The basic process comprises contacting the nitrile with hydrogen at low pressure in the presence of a catalyst under conditions sufficient to effect the conversion of the nitrile to the primary amine product.