methyl 11-cyclohexyl-6-hydroxy-8-methoxy-6H-isoindolo[2,1-a]indole-3-carboxylate

Base Information

Chemical Name:methyl 11-cyclohexyl-6-hydroxy-8-methoxy-6H-isoindolo[2,1-a]indole-3-carboxylate
CAS No.:902147-82-4
Molecular Formula:C₂₄H₂₅NO₄
Molecular Weight:391.467
Hs Code.:

Synonyms:methyl 11-cyclohexyl-6-hydroxy-8-methoxy-6H-isoindolo[2,1-a]indole-3-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 11-cyclohexyl-6-hydroxy-8-methoxy-6H-isoindolo[2,1-a]indole-3-carboxylate

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Technology Process of methyl 11-cyclohexyl-6-hydroxy-8-methoxy-6H-isoindolo[2,1-a]indole-3-carboxylate

There total 7 articles about methyl 11-cyclohexyl-6-hydroxy-8-methoxy-6H-isoindolo[2,1-a]indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 494799-19-8
methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate

: 139962-95-1
2-formyl-4-methoxyphenylboronic acid

: 902147-82-4
methyl 11-cyclohexyl-6-hydroxy-8-methoxy-6H-isoindolo[2,1-a]indole-3-carboxylate

Guidance literature:: With sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 100 ℃; for 3h;

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 902147-82-4
methyl 11-cyclohexyl-6-hydroxy-8-methoxy-6H-isoindolo[2,1-a]indole-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylsilane; trifluoroacetic acid / dichloromethane / 12 h / 10 - 20 °C

2: pyridinium hydrobromide perbromide / tetrahydrofuran; chloroform / 2 - 2.66 h / 0 - 20 °C

3: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 3 h / 100 °C

With triethylsilane; sodium carbonate; pyridinium hydrobromide perbromide; trifluoroacetic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; toluene;

Reference yield:

: 1670-82-2,261352-47-0
Indole-6-carboxylic acid

: 902147-82-4
methyl 11-cyclohexyl-6-hydroxy-8-methoxy-6H-isoindolo[2,1-a]indole-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl ether / 1 h / -15 °C

2: triethylsilane; trifluoroacetic acid / dichloromethane / 12 h / 10 - 20 °C

3: pyridinium hydrobromide perbromide / tetrahydrofuran; chloroform / 2 - 2.66 h / 0 - 20 °C

4: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 3 h / 100 °C

With triethylsilane; sodium carbonate; pyridinium hydrobromide perbromide; trifluoroacetic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; chloroform; water; toluene;