methyl 1-[benzyl(dimethoxyphosphoryl)amino]cyclohexanecarboxylate

Base Information

• Chemical Name: methyl 1-[benzyl(dimethoxyphosphoryl)amino]cyclohexanecarboxylate
• CAS No.: 1396787-55-5
• Molecular Formula: C₁₈H₂₈NO₅P
• Molecular Weight: 369.398
• Mol file: 1396787-55-5.mol

Synonyms:methyl 1-[benzyl(dimethoxyphosphoryl)amino]cyclohexanecarboxylate

Chemical Property of methyl 1-[benzyl(dimethoxyphosphoryl)amino]cyclohexanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of methyl 1-[benzyl(dimethoxyphosphoryl)amino]cyclohexanecarboxylate

There total 2 articles about methyl 1-[benzyl(dimethoxyphosphoryl)amino]cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methyl 1-(benzylamino)cyclohexanecarboxylate (1182822-73-6) + trifluoromethanesulfonic acid-[dimethoxyphosphinyl]-methyl ester (96851-20-6) → methyl 1-[benzyl(dimethoxyphosphoryl)amino]cyclohexanecarboxylate (1396787-55-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1021/ol302096j

Reference yield:

benzyl bromide (100-39-0) + 1-amino-cyclohexanecarboxylic acid methyl ester hydrochloride (37993-32-1) → methyl 1-[benzyl(dimethoxyphosphoryl)amino]cyclohexanecarboxylate (1396787-55-5)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 80 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 6 h / 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; In acetonitrile;

DOI:10.1021/ol302096j

upstream raw materials:

benzyl bromide

1-amino-cyclohexanecarboxylic acid methyl ester hydrochloride

methyl 1-(benzylamino)cyclohexanecarboxylate

trifluoromethanesulfonic acid-[dimethoxyphosphinyl]-methyl ester