4-(2-{2-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenoxy]-ethoxy}-ethyl)-benzonitrile

Base Information

Chemical Name:4-(2-{2-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenoxy]-ethoxy}-ethyl)-benzonitrile
CAS No.:86902-01-4
Molecular Formula:C₂₃H₃₀N₂O₄
Molecular Weight:398.502
Hs Code.:

Synonyms:4-(2-{2-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenoxy]-ethoxy}-ethyl)-benzonitrile

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Chemical Property of 4-(2-{2-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenoxy]-ethoxy}-ethyl)-benzonitrile

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Technology Process of 4-(2-{2-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenoxy]-ethoxy}-ethyl)-benzonitrile

There total 8 articles about 4-(2-{2-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenoxy]-ethoxy}-ethyl)-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60-12-8
2-phenylethanol

: 86902-01-4
4-(2-{2-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenoxy]-ethoxy}-ethyl)-benzonitrile

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) NaH / 1.) DMF, 60 deg C, 10 min, 2.) DMF, 60 deg C, 30 min

2: 92 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / Ambient temperature

3: 0.5 h / 50 °C

4: 1.) HNO₃, 2.) 2percent ethanol. HCl / 1.) from -20 deg C to -15 deg C, 30 min, 2.) reflux, 1 h

5: 100 percent / H₂ / 10percent Pd/C / ethanol / 1.25 h / Ambient temperature

6: 1.) NaNO₂, aq. HCl, 2.) Na₂CO₃ / 1.) from -5 deg C to 0 deg C, 2.) H₂O, toluene, 50 deg C, 5 min

7: pyridine / 0.5 h

8: 1.) NaH / 1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; hydrogen; nitric acid; sodium hydride; sodium carbonate; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00365a005

Reference yield:

: acetic acid-(2-phenethyloxy-ethyl ester)

: 86902-01-4
4-(2-{2-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenoxy]-ethoxy}-ethyl)-benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) HNO₃, 2.) 2percent ethanol. HCl / 1.) from -20 deg C to -15 deg C, 30 min, 2.) reflux, 1 h

2: 100 percent / H₂ / 10percent Pd/C / ethanol / 1.25 h / Ambient temperature

3: 1.) NaNO₂, aq. HCl, 2.) Na₂CO₃ / 1.) from -5 deg C to 0 deg C, 2.) H₂O, toluene, 50 deg C, 5 min

4: pyridine / 0.5 h

5: 1.) NaH / 1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min

With pyridine; hydrogenchloride; hydrogen; nitric acid; sodium hydride; sodium carbonate; sodium nitrite; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00365a005

Reference yield:

: 81228-03-7
2-phenethyloxyacetic acid

: 86902-01-4
4-(2-{2-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenoxy]-ethoxy}-ethyl)-benzonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: 92 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / Ambient temperature

2: 0.5 h / 50 °C

3: 1.) HNO₃, 2.) 2percent ethanol. HCl / 1.) from -20 deg C to -15 deg C, 30 min, 2.) reflux, 1 h

4: 100 percent / H₂ / 10percent Pd/C / ethanol / 1.25 h / Ambient temperature

5: 1.) NaNO₂, aq. HCl, 2.) Na₂CO₃ / 1.) from -5 deg C to 0 deg C, 2.) H₂O, toluene, 50 deg C, 5 min

6: pyridine / 0.5 h

7: 1.) NaH / 1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; hydrogen; nitric acid; sodium hydride; sodium carbonate; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00365a005