[R,S]-methyl [2-cyano-5-(thien-3-yl)methoxy]phenoxyphenylacetate

Base Information

Chemical Name:[R,S]-methyl [2-cyano-5-(thien-3-yl)methoxy]phenoxyphenylacetate
CAS No.:181039-82-7
Molecular Formula:C₂₁H₁₇NO₄S
Molecular Weight:379.436
Hs Code.:

Synonyms:[R,S]-methyl [2-cyano-5-(thien-3-yl)methoxy]phenoxyphenylacetate

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Chemical Property of [R,S]-methyl [2-cyano-5-(thien-3-yl)methoxy]phenoxyphenylacetate

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Technology Process of [R,S]-methyl [2-cyano-5-(thien-3-yl)methoxy]phenoxyphenylacetate

There total 6 articles about [R,S]-methyl [2-cyano-5-(thien-3-yl)methoxy]phenoxyphenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 37167-62-7,3042-81-7,61139-20-6
bromo-phenyl-acetic acid methyl ester

: 170282-49-2
2-hydroxy-4-(thien-3-ylmethoxy)benzonitrile

: 181039-82-7
[R,S]-methyl [2-cyano-5-(thien-3-yl)methoxy]phenoxyphenylacetate

Guidance literature:: 2-hydroxy-4-(thien-3-ylmethoxy)benzonitrile; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

bromo-phenyl-acetic acid methyl ester; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Further stages.;
DOI:10.1021/jm990378b

Reference yield:

: 4358-87-6
(RS)-methyl mandelate

: 181039-82-7
[R,S]-methyl [2-cyano-5-(thien-3-yl)methoxy]phenoxyphenylacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: SOBr₂ / toluene / 20 °C

2.1: NaH / dimethylformamide / 0.17 h / 20 °C

2.2: 56 percent / dimethylformamide / 1 h / 20 °C

With sulfurous dibromide; sodium hydride; In N,N-dimethyl-formamide; toluene; 1.1: Bromination / 2.1: Metallation / 2.2: Substitution;
DOI:10.1021/jm990378b

Reference yield:

: 100-52-7
benzaldehyde

: 181039-82-7
[R,S]-methyl [2-cyano-5-(thien-3-yl)methoxy]phenoxyphenylacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: aq. KOH; LiCl / dioxane / 10 - 15 °C

2.1: H₂SO₄ / Heating

3.1: SOBr₂ / toluene / 20 °C

4.1: NaH / dimethylformamide / 0.17 h / 20 °C

4.2: 56 percent / dimethylformamide / 1 h / 20 °C

With potassium hydroxide; sulfurous dibromide; sulfuric acid; sodium hydride; lithium chloride; In 1,4-dioxane; N,N-dimethyl-formamide; toluene; 1.1: Addition / 2.1: Esterification / 3.1: Bromination / 4.1: Metallation / 4.2: Substitution;
DOI:10.1021/jm990378b