N-[(E)-2-[4-(t-butyldimethylsiloxymethyl)benzyloxyimino]ethanonyl]bornane-10,2-sultam

Base Information

• Chemical Name: N-[(E)-2-[4-(t-butyldimethylsiloxymethyl)benzyloxyimino]ethanonyl]bornane-10,2-sultam
• CAS No.: 278793-27-4
• Molecular Formula: C₂₆H₄₀N₂O₅SSi
• Molecular Weight: 520.766
• Mol file: 278793-27-4.mol

Synonyms:N-[(E)-2-[4-(t-butyldimethylsiloxymethyl)benzyloxyimino]ethanonyl]bornane-10,2-sultam

Chemical Property of N-[(E)-2-[4-(t-butyldimethylsiloxymethyl)benzyloxyimino]ethanonyl]bornane-10,2-sultam

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(E)-2-[4-(t-butyldimethylsiloxymethyl)benzyloxyimino]ethanonyl]bornane-10,2-sultam

There total 8 articles about N-[(E)-2-[4-(t-butyldimethylsiloxymethyl)benzyloxyimino]ethanonyl]bornane-10,2-sultam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(+)-camphorsultam (108448-77-7,124224-04-0) + methyl (E)-2-[4-(t-butyldimethylsiloxymethyl)benzyloxyimino]ethanate (278793-19-4) → N-[(E)-2-[4-(t-butyldimethylsiloxymethyl)benzyloxyimino]ethanonyl]bornane-10,2-sultam (278793-27-4)

Guidance literature:

With trimethylaluminum; In hexane; 1,2-dichloro-ethane; for 24h; Heating;

DOI:10.1248/cpb.51.540

Reference yield:

[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)phenyl]methanol (118992-89-5) → N-[(E)-2-[4-(t-butyldimethylsiloxymethyl)benzyloxyimino]ethanonyl]bornane-10,2-sultam (278793-27-4)

Guidance literature:

Multi-step reaction with 5 steps

1: Et₃N / CH₂Cl₂ / 1 h / 0 °C

2: 9.0 g / Et₃N / CH₂Cl₂ / 8 h / Heating

3: hydrazine monohydrate / methanol / 1 h / 20 °C

4: 9.4 g / methanol / 8 h / 20 °C

5: 100 percent / Me₃Al / 1,2-dichloro-ethane; hexane / 24 h / Heating

With trimethylaluminum; hydrazine hydrate; triethylamine; In methanol; hexane; dichloromethane; 1,2-dichloro-ethane;

DOI:10.1248/cpb.51.540

Reference yield:

N-[4-(t-butyldimethylsiloxymethyl)benzyloxy]phthalimide (278793-18-3) → N-[(E)-2-[4-(t-butyldimethylsiloxymethyl)benzyloxyimino]ethanonyl]bornane-10,2-sultam (278793-27-4)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine monohydrate / methanol / 1 h / 20 °C

2: 9.4 g / methanol / 8 h / 20 °C

3: 100 percent / Me₃Al / 1,2-dichloro-ethane; hexane / 24 h / Heating

With trimethylaluminum; hydrazine hydrate; In methanol; hexane; 1,2-dichloro-ethane;

DOI:10.1248/cpb.51.540

upstream raw materials:

(+)-camphorsultam

methyl (E)-2-[4-(t-butyldimethylsiloxymethyl)benzyloxyimino]ethanate

p-xylylene glycol

[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)phenyl]methanol

Downstream raw materials:

N-[(E)-2-(4-(hydroxymethyl)benzyloxyimino)ethanonyl]bornane-10,2-sultam glutaric acid monoester