methyl 2-cyclopropyl-7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate

Base Information

Chemical Name:methyl 2-cyclopropyl-7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate
CAS No.:1369959-26-1
Molecular Formula:C₁₈H₁₇Cl₂N₃O₂
Molecular Weight:378.258
Hs Code.:

Synonyms:methyl 2-cyclopropyl-7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate

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Chemical Property of methyl 2-cyclopropyl-7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate

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Technology Process of methyl 2-cyclopropyl-7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate

There total 1 articles about methyl 2-cyclopropyl-7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 175137-46-9
5-cyclopropyl-2H-pyrazol-3-ylamine

: 105-45-3
acetoacetic acid methyl ester

: 6287-38-3
3,4-dichlorobenzaldehyde

: 1369959-26-1
methyl 2-cyclopropyl-7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate

Guidance literature:: With piperidine; In tetrahydrofuran; n-heptane; at 75 ℃; Inert atmosphere;
DOI:10.1021/jm201386u

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1369959-26-1
methyl 2-cyclopropyl-7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate

: C₂₃H₂₅Cl₂N₃O₄

Guidance literature:: With dmap; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm201386u

Reference yield:

: 1369959-26-1
methyl 2-cyclopropyl-7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate

: C₃₀H₃₃Cl₂N₅O₄

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.1: lithium hydroxide / tetrahydrofuran; water / 15 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 14 h / 20 °C / Inert atmosphere

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm201386u