(S)-N-((3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methyl)propionamide

Base Information

Chemical Name:(S)-N-((3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methyl)propionamide
CAS No.:1430321-55-3
Molecular Formula:C₁₉H₂₇F₂N₃O₃Si
Molecular Weight:411.524
Hs Code.:

Synonyms:(S)-N-((3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methyl)propionamide

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Chemical Property of (S)-N-((3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methyl)propionamide

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Technology Process of (S)-N-((3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methyl)propionamide

There total 10 articles about (S)-N-((3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methyl)propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1430321-53-1
(S)-5-(aminomethyl)-3-(4-(4,4-diniethyl-1,4-azasilinan-1-yl)-3,5-difluorophenyl)oxazolidin-2-one

: 79-03-8
propionyl chloride

: 1430321-55-3
(S)-N-((3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methyl)propionamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 25 ℃; for 3h;

Reference yield:

: 1430321-67-7
benzyl (4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3,5-difluorophenyl)carbamate

: 1430321-55-3
(S)-N-((3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methyl)propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium tert-butoxide / N,N-dimethyl-formamide / 45 h / 0 - 25 °C

2: trifluoroacetic acid / dichloromethane / 3 h / 25 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 0 - 25 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium tert-butoxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1430321-66-6
1-(2,6-difluoro-4-nitrophenyl)-4,4-dimethyl-1,4-azasilinane

: 1430321-55-3
(S)-N-((3-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methyl)propionamide

Guidance literature:: Multi-step reaction with 5 steps

1: palladium on activated charcoal; hydrogen / tetrahydrofuran / 1810.07 Torr

2: sodium hydrogencarbonate / tetrahydrofuran / 5 h / 25 °C

3: lithium tert-butoxide / N,N-dimethyl-formamide / 45 h / 0 - 25 °C

4: trifluoroacetic acid / dichloromethane / 3 h / 25 °C

5: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 0 - 25 °C

With palladium on activated charcoal; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium tert-butoxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;