[(1R)-2-[tert-butyl(dimethyl)silyl]oxy-1-methyl-ethyl]benzoate

Base Information

• Chemical Name: [(1R)-2-[tert-butyl(dimethyl)silyl]oxy-1-methyl-ethyl]benzoate
• CAS No.: 871580-89-1
• Molecular Formula: C₁₆H₂₆O₃Si
• Molecular Weight: 294.466
• Mol file: 871580-89-1.mol

Synonyms:[(1R)-2-[tert-butyl(dimethyl)silyl]oxy-1-methyl-ethyl]benzoate

Chemical Property of [(1R)-2-[tert-butyl(dimethyl)silyl]oxy-1-methyl-ethyl]benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(1R)-2-[tert-butyl(dimethyl)silyl]oxy-1-methyl-ethyl]benzoate

There total 4 articles about [(1R)-2-[tert-butyl(dimethyl)silyl]oxy-1-methyl-ethyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(2R)-1[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-propanol (136918-07-5) + benzoic acid (65-85-0,8013-63-6) → [(1R)-2-[tert-butyl(dimethyl)silyl]oxy-1-methyl-ethyl]benzoate (871580-89-1)

Guidance literature:

With dicyclohexyl-carbodiimide; dmap; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → [(1R)-2-[tert-butyl(dimethyl)silyl]oxy-1-methyl-ethyl]benzoate (871580-89-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 0 °C

2: dmap / dichloromethane / 0 - 20 °C

With pyridine; dmap; In dichloromethane;

DOI:10.1021/jacs.5b08858

Reference yield:

benzoyl chloride (98-88-4) + (2R)-1[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-propanol (136918-07-5) → [(1R)-2-[tert-butyl(dimethyl)silyl]oxy-1-methyl-ethyl]benzoate (871580-89-1)

Guidance literature:

With pyridine; at 0 - 5 ℃;

DOI:10.1016/j.tetasy.2005.03.019

upstream raw materials:

benzoyl chloride

(2R)-1[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-propanol

tert-butyldimethylsilyl chloride

benzoic acid

Downstream raw materials:

[(1R)-2-hydroxy-1-methyl-ethyl]benzoate

(R)-1-oxopropan-2-yl benzoate

(1R)-2-bromo-1-methylethyl benzoate