Technology Process of 3-benzyl-4,5-dioxohexanoic acid tert-butyl ester
There total 7 articles about 3-benzyl-4,5-dioxohexanoic acid tert-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
bisacenaphthenethiophene; oxygen;
In
dichloromethane;
at -78 ℃;
for 1.8h;
Yield given;
Irradiation;
DOI:10.1021/jo00356a036
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) n-butyllithium, diisopropylamine / 1.) THF, hexane, -78 deg C, 7 min, 2.) THF, hexane, 0 deg C, 15 min
2: 88 percent / aq. KOH / ethanol / 4.2 h
3: 74 percent / N,N-dicyclohexylcarbodiimide (DCC) / ethyl acetate / -5 - 20 °C
4: 98 percent / tetrahydrofuran / 0.5 h / 0 °C
5: 12 h / 75 °C
6: O2, bisacenaphthenethiophene / CH2Cl2 / 1.8 h / -78 °C / Irradiation
With
potassium hydroxide; n-butyllithium; bisacenaphthenethiophene; oxygen; diisopropylamine; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; ethanol; dichloromethane; ethyl acetate;
DOI:10.1021/jo00356a036
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) n-butyllithium, diisopropylamine / 1.) THF, hexane, -78 deg C, 7 min, 2.) THF, hexane, 0 deg C, 15 min
2: 88 percent / aq. KOH / ethanol / 4.2 h
3: 74 percent / N,N-dicyclohexylcarbodiimide (DCC) / ethyl acetate / -5 - 20 °C
4: 98 percent / tetrahydrofuran / 0.5 h / 0 °C
5: 12 h / 75 °C
6: O2, bisacenaphthenethiophene / CH2Cl2 / 1.8 h / -78 °C / Irradiation
With
potassium hydroxide; n-butyllithium; bisacenaphthenethiophene; oxygen; diisopropylamine; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; ethanol; dichloromethane; ethyl acetate;
DOI:10.1021/jo00356a036
