Technology Process of (E)-3-Benzyl-6-dimethylamino-5-methyl-4-oxo-hex-5-enoic acid tert-butyl ester
There total 5 articles about (E)-3-Benzyl-6-dimethylamino-5-methyl-4-oxo-hex-5-enoic acid tert-butyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) n-butyllithium, diisopropylamine / 1.) THF, hexane, -78 deg C, 7 min, 2.) THF, hexane, 0 deg C, 15 min
2: 88 percent / aq. KOH / ethanol / 4.2 h
3: 74 percent / N,N-dicyclohexylcarbodiimide (DCC) / ethyl acetate / -5 - 20 °C
4: 98 percent / tetrahydrofuran / 0.5 h / 0 °C
5: 12 h / 75 °C
With
potassium hydroxide; n-butyllithium; diisopropylamine; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; ethanol; ethyl acetate;
DOI:10.1021/jo00356a036
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) n-butyllithium, diisopropylamine / 1.) THF, hexane, -78 deg C, 7 min, 2.) THF, hexane, 0 deg C, 15 min
2: 88 percent / aq. KOH / ethanol / 4.2 h
3: 74 percent / N,N-dicyclohexylcarbodiimide (DCC) / ethyl acetate / -5 - 20 °C
4: 98 percent / tetrahydrofuran / 0.5 h / 0 °C
5: 12 h / 75 °C
With
potassium hydroxide; n-butyllithium; diisopropylamine; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; ethanol; ethyl acetate;
DOI:10.1021/jo00356a036
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 74 percent / N,N-dicyclohexylcarbodiimide (DCC) / ethyl acetate / -5 - 20 °C
2: 98 percent / tetrahydrofuran / 0.5 h / 0 °C
3: 12 h / 75 °C
With
dicyclohexyl-carbodiimide;
In
tetrahydrofuran; ethyl acetate;
DOI:10.1021/jo00356a036
