Technology Process of 3-benzyl-4-oxohexanoic acid tert-butyl ester
There total 5 articles about 3-benzyl-4-oxohexanoic acid tert-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) n-butyllithium, diisopropylamine / 1.) THF, hexane, -78 deg C, 7 min, 2.) THF, hexane, 0 deg C, 15 min
2: 88 percent / aq. KOH / ethanol / 4.2 h
3: 74 percent / N,N-dicyclohexylcarbodiimide (DCC) / ethyl acetate / -5 - 20 °C
4: 98 percent / tetrahydrofuran / 0.5 h / 0 °C
With
potassium hydroxide; n-butyllithium; diisopropylamine; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; ethanol; ethyl acetate;
DOI:10.1021/jo00356a036
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) n-butyllithium, diisopropylamine / 1.) THF, hexane, -78 deg C, 7 min, 2.) THF, hexane, 0 deg C, 15 min
2: 88 percent / aq. KOH / ethanol / 4.2 h
3: 74 percent / N,N-dicyclohexylcarbodiimide (DCC) / ethyl acetate / -5 - 20 °C
4: 98 percent / tetrahydrofuran / 0.5 h / 0 °C
With
potassium hydroxide; n-butyllithium; diisopropylamine; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; ethanol; ethyl acetate;
DOI:10.1021/jo00356a036
