4,11-bis(1-benzyl-1H-[1,2,3]triazol-4-ylmethyl)-1,4,8,11-tetraaza-cyclotetradecane

Base Information

Chemical Name:4,11-bis(1-benzyl-1H-[1,2,3]triazol-4-ylmethyl)-1,4,8,11-tetraaza-cyclotetradecane
CAS No.:1221749-40-1
Molecular Formula:C₃₀H₄₂N₁₀
Molecular Weight:542.73
Hs Code.:

Synonyms:4,11-bis(1-benzyl-1H-[1,2,3]triazol-4-ylmethyl)-1,4,8,11-tetraaza-cyclotetradecane

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Chemical Property of 4,11-bis(1-benzyl-1H-[1,2,3]triazol-4-ylmethyl)-1,4,8,11-tetraaza-cyclotetradecane

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Technology Process of 4,11-bis(1-benzyl-1H-[1,2,3]triazol-4-ylmethyl)-1,4,8,11-tetraaza-cyclotetradecane

There total 4 articles about 4,11-bis(1-benzyl-1H-[1,2,3]triazol-4-ylmethyl)-1,4,8,11-tetraaza-cyclotetradecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1221749-39-8
4,11-bis(1-benzyl-1H-[1,2,3]triazol-4-ylmethyl)-1,4,8,11-tetraazacyclotetradecane-1,8-dicarboxylic acid di-tert-butyl ester

: 1221749-40-1
4,11-bis(1-benzyl-1H-[1,2,3]triazol-4-ylmethyl)-1,4,8,11-tetraaza-cyclotetradecane

Guidance literature:: 4,11-bis(1-benzyl-1H-[1,2,3]triazol-4-ylmethyl)-1,4,8,11-tetraazacyclotetradecane-1,8-dicarboxylic acid di-tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 0.5h;

With sodium hydroxide; In dichloromethane; water;
DOI:10.1021/acs.jmedchem.7b01569

Reference yield:

: 75920-10-4
1,4,8,11-tetraazatricyclo[9.3.1.14,8]hexadecane

: 1221749-40-1
4,11-bis(1-benzyl-1H-[1,2,3]triazol-4-ylmethyl)-1,4,8,11-tetraaza-cyclotetradecane

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetonitrile; toluene / 20 °C

1.2: 1 h / 20 °C

1.3: 20 °C

2.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

With hydrogenchloride; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In tetrahydrofuran; 1,4-dioxane; water; toluene; acetonitrile;
DOI:10.1021/acs.jmedchem.7b01569

Reference yield:

: 100-39-0
benzyl bromide

: 1221749-40-1
4,11-bis(1-benzyl-1H-[1,2,3]triazol-4-ylmethyl)-1,4,8,11-tetraaza-cyclotetradecane

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide / water; acetone / 2 h / 20 °C

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

With hydrogenchloride; sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In tetrahydrofuran; 1,4-dioxane; water; acetone;
DOI:10.1021/acs.jmedchem.7b01569