1,4,8,11-Tetraazatricyclo[9.3.1.1(4,8)]hexadecane

Base Information

• Chemical Name: 1,4,8,11-Tetraazatricyclo[9.3.1.1(4,8)]hexadecane
• CAS No.: 75920-10-4
• Molecular Formula: C12H24 N4
• Molecular Weight: 224.349
• Hs Code.: 2933990090
• Mol file: 75920-10-4.mol

Synonyms:NSC 358063

Chemical Property of 1,4,8,11-Tetraazatricyclo[9.3.1.1(4,8)]hexadecane

Chemical Property:

• Vapor Pressure: 0.000242mmHg at 25°C
• Melting Point: 83-85°C
• Refractive Index: 1.596
• Boiling Point: 324.6°C at 760 mmHg
• Flash Point: 136.2°C
• PSA: 12.96000
• Density: 1.14g/cm³
• LogP: -0.31800
• Sensitive.: Hygroscopic

Purity/Quality:

99% ^*data from raw suppliers

1,4,8,11-TETRAAZATRICYCLO[9.3.1.1(4,8)]HEXADECANE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4,8,11-Tetraazatricyclo[9.3.1.1(4,8)]hexadecane

There total 5 articles about 1,4,8,11-Tetraazatricyclo[9.3.1.1(4,8)]hexadecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,4,8,11-Tetraazacyclotetradecane (295-37-4) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → 1,4,8,11-tetraazatricyclo[9.3.1.14,8]hexadecane (75920-10-4)

Guidance literature:

In water; at 20 ℃; for 4h;

DOI:10.1021/acs.inorgchem.5b01779

Reference yield: 97.0%

1,4,8,11-Tetraazacyclotetradecane (295-37-4) → 1,4,8,11-tetraazatricyclo[9.3.1.14,8]hexadecane (75920-10-4)

Guidance literature:

With formaldehyd; In water; at 20 ℃;

DOI:10.1021/ml400142s

Reference yield: 95.0%

1,4,8,11-Tetraazacyclotetradecane (295-37-4) + dichloromethane (75-09-2) → 1,4,8,11-tetraazatricyclo[9.3.1.14,8]hexadecane (75920-10-4)

Guidance literature:

With sodium hydroxide;

DOI:10.1055/s-1997-975

upstream raw materials:

1,4,8,11-Tetraazacyclotetradecane

formaldehyd

dichloromethane

1,4,8,11-tetraazabicyclo[9.3.1]pentadecane

Downstream raw materials:

1,8-Dimethyl-1,4,8,11-tetraazacyclotetradecane

1,4-dimethyl-1,4,8,11-tetraazacyclotetradecane

4,11-bis(1-benzyl-1H-[1,2,3]triazol-4-ylmethyl)-1,4,8,11-tetraaza-cyclotetradecane

4,11-bis(1-benzyl-1H-[1,2,3]triazol-4-ylmethyl)-1,4,8,11-tetraazacyclotetradecane-1,8-dicarboxylic acid di-tert-butyl ester

Refernces

• 1、 Dale, Ajit V.,Pandya, Darpan N.,Kim, Jung Young,Lee, Hochun,Ha, Yeong Su,Bhatt, Nikunj,Kim, Jonghee,Seo, Jeong Ju,Lee, Woonghee,Kim, Sung Hong,Yoon, Young-Ran,An, Gwang Il,Yoo, Jeongsoo. "Non-cross-bridged tetraazamacrocyclic chelator for stable 64Cu-based radiopharmaceuticals". . p. 927 - 931. Retrieved 2013.
• 2、 Wong, Joseph K.-H.,Ast, Sandra,Yu, Mingfeng,Flehr, Roman,Counsell, Andrew J.,Turner, Peter,Crisologo, Patrick,Todd, Matthew H.,Rutledge, Peter J.. "Synthesis and Evaluation of 1,8-Disubstituted-Cyclam/Naphthalimide Conjugates as Probes for Metal Ions". . p. 375 - 385. Retrieved 2016.
• 3、 Counsell, Andrew J.,Yu, Mingfeng,Shi, Mengying,Jones, Angus T.,Batten, James M.,Turner, Peter,Todd, Matthew H.,Rutledge, Peter J.. "Copper(ii) complexes ofN-propargyl cyclam ligands reveal a range of coordination modes and colours, and unexpected reactivity". supporting information. p. 3931 - 3942. Retrieved 2021/03/29.
• 4、 Abozeid, Samira M.,Asik, Didar,Lovell, Jonathan F.,Morrow, Janet R.,Nazarenko, Alexander Y.,Sokolow, Gregory E.. "CoII Complexes as Liposomal CEST Agents". supporting information. p. 12093 - 12097. Retrieved 2020/05/22.