Dexbudesonide

Base Information

Chemical Name:Dexbudesonide
CAS No.:51372-29-3
Molecular Formula:C25H34O6
Molecular Weight:430.541
Hs Code.:2914509090
European Community (EC) Number:257-161-7,257-139-7
UNII:2HI1006KPH
DSSTox Substance ID:DTXSID401017799
Nikkaji Number:J261.702A
Wikipedia:Budesonide,Dexbudesonide
Wikidata:Q27254753
NCI Thesaurus Code:C80814
ChEMBL ID:CHEMBL2110662
Mol file:51372-29-3.mol

Synonyms:Budesonide;Budesonide, (R)-Isomer;Budesonide, (S)-Isomer;Horacort;Pulmicort;Rhinocort;Tarpeyo

Suppliers and Price of Dexbudesonide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(22R)-Budesonide
1mg
$ 185.00

Biosynth Carbosynth
(22R)-Budesonide
2 mg
$ 500.00

Biosynth Carbosynth
(22R)-Budesonide
1 mg
$ 280.00

Biosynth Carbosynth
(22R)-Budesonide
10 mg
$ 1750.00

Biosynth Carbosynth
(22R)-Budesonide
5 mg
$ 1100.00

Biosynth Carbosynth
(22R)-Budesonide
25 mg
$ 2800.00

American Custom Chemicals Corporation
TRIAMCINOLONE-D5 95.00%
10MG
$ 2194.50

American Custom Chemicals Corporation
TRIAMCINOLONE-D5 95.00%
1MG
$ 779.63

Total 72 raw suppliers

Chemical Property of Dexbudesonide

Chemical Property:

Appearance/Colour:light beige solid
Melting Point:194-199 °C
Boiling Point:599.7 °C at 760 mmHg
PKA:12.87±0.10(Predicted)
Flash Point:201.8 °C
PSA：93.06000
Density:1.27 g/cm³
LogP:2.71680
Storage Temp.:-20°C Freezer
Solubility.:Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly, Heated)
XLogP3:2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:430.23553880
Heavy Atom Count:31
Complexity:862

Purity/Quality:

99% ^*data from raw suppliers

(22R)-Budesonide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCC1OC2CC3C4CCC5=CC(=O)C=CC5(C4C(CC3(C2(O1)C(=O)CO)C)O)C
Isomeric SMILES:CCC[C@@H]1O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@@]5([C@H]4[C@H](C[C@@]3([C@@]2(O1)C(=O)CO)C)O)C
Recent EU Clinical Trials:Increase in inhaled corticosteroid dose vs triple therapy in T2-high asthma patients who remain uncontrolled with medium dose inhaled corticosteroids/long-acting β2 adrenergic combination: a real-life study. TRICORDA Study (Triple vs Inhalados CORticoides a Dosis Altas).
Uses Budesonide (B689490) epimer R Labelled Triamcinolone. Triamcinolone is a glucocorticoid. Triamcinolone is used as an antiasthmatic (inhalant); antiallergic (nasal).

Technology Process of Dexbudesonide

There total 10 articles about Dexbudesonide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.6%