methyl 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)isonicotinate

Base Information

Chemical Name:methyl 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)isonicotinate
CAS No.:1202928-07-1
Molecular Formula:C₁₆H₁₃FN₄O₃
Molecular Weight:328.303
Hs Code.:

Synonyms:methyl 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)isonicotinate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)isonicotinate

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Technology Process of methyl 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)isonicotinate

There total 5 articles about methyl 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)isonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1202928-07-1
methyl 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)isonicotinate

Guidance literature:

Reference yield:

: 1202927-95-4
methyl 2-(5-oxo-1H-1,2,4-triazol-4(5H)-yl)isonicotinate

: 459-46-1
4-Fluorobenzyl bromide

: 1202928-07-1
methyl 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)isonicotinate

Guidance literature:: methyl 2-(5-oxo-1H-1,2,4-triazol-4(5H)-yl)isonicotinate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 1h;

4-Fluorobenzyl bromide; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃;

Reference yield:

: 6937-03-7
methyl 2-aminoisonicotinate

: 1202928-07-1
methyl 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)isonicotinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / tetrahydrofuran; dichloromethane / 0 - 20 °C

2.1: hydrazine hydrate / tetrahydrofuran / 17 h / 20 °C

3.1: toluene-4-sulfonic acid / ethanol / 4 h / 20 °C / Reflux

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

4.2: 0 - 20 °C

With pyridine; sodium hydride; toluene-4-sulfonic acid; hydrazine hydrate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;