N-benzyl-2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)isonicotinamide

Base Information

Chemical Name:N-benzyl-2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)isonicotinamide
CAS No.:1202927-34-1
Molecular Formula:C₂₂H₁₈FN₅O₂
Molecular Weight:403.416
Hs Code.:

Synonyms:N-benzyl-2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)isonicotinamide

Suppliers and Price of N-benzyl-2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)isonicotinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-benzyl-2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)isonicotinamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-benzyl-2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)isonicotinamide

There total 5 articles about N-benzyl-2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 1202928-07-1
methyl 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)isonicotinate

: 100-46-9
benzylamine

: 1202927-34-1
N-benzyl-2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)isonicotinamide

Guidance literature:: With sodium cyanide; at 100 - 110 ℃; for 26h;

Reference yield:

: 6937-03-7
methyl 2-aminoisonicotinate

: 1202927-34-1
N-benzyl-2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)isonicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / tetrahydrofuran; dichloromethane / 0 - 20 °C

2.1: hydrazine hydrate / tetrahydrofuran / 17 h / 20 °C

3.1: toluene-4-sulfonic acid / ethanol / 4 h / 20 °C / Reflux

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

4.2: 0 - 20 °C

5.1: sodium cyanide / 26 h / 100 - 110 °C

With pyridine; sodium cyanide; sodium hydride; toluene-4-sulfonic acid; hydrazine hydrate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1202927-94-3
metyl 2-(hydrazinecarboxamido)isonicotinate

: 1202927-34-1
N-benzyl-2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)isonicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / ethanol / 4 h / 20 °C / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

2.2: 0 - 20 °C

3.1: sodium cyanide / 26 h / 100 - 110 °C

With sodium cyanide; sodium hydride; toluene-4-sulfonic acid; In ethanol; N,N-dimethyl-formamide; mineral oil;