1-({4-[(4-bromobenzoyl)amino]-3,4,5,6-tetrahydro-2H-pyran-4-yl}carbonyl)-L-proline

Base Information

• Chemical Name: 1-({4-[(4-bromobenzoyl)amino]-3,4,5,6-tetrahydro-2H-pyran-4-yl}carbonyl)-L-proline
• CAS No.: 1482285-99-3
• Molecular Formula: C₁₈H₂₁BrN₂O₅
• Molecular Weight: 425.279

Synonyms:1-({4-[(4-bromobenzoyl)amino]-3,4,5,6-tetrahydro-2H-pyran-4-yl}carbonyl)-L-proline

Chemical Property of 1-({4-[(4-bromobenzoyl)amino]-3,4,5,6-tetrahydro-2H-pyran-4-yl}carbonyl)-L-proline

Chemical Property:

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Technology Process of 1-({4-[(4-bromobenzoyl)amino]-3,4,5,6-tetrahydro-2H-pyran-4-yl}carbonyl)-L-proline

There total 3 articles about 1-({4-[(4-bromobenzoyl)amino]-3,4,5,6-tetrahydro-2H-pyran-4-yl}carbonyl)-L-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl 1-({4-[(4-bromobenzoyl)amino]-3,4,5,6-tetrahydro-2H-pyran-4-yl}carbonyl)-L-prolinate (1482285-98-2) → 1-({4-[(4-bromobenzoyl)amino]-3,4,5,6-tetrahydro-2H-pyran-4-yl}carbonyl)-L-proline (1482285-99-3)

Guidance literature:

With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃; for 23h;

DOI:10.1002/hlca.201300062

Reference yield:

4-Bromobenzoic acid (586-76-5) → 1-({4-[(4-bromobenzoyl)amino]-3,4,5,6-tetrahydro-2H-pyran-4-yl}carbonyl)-L-proline (1482285-99-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 45 h / 0 - 20 °C

2: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 23 h / 20 °C

With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol;

DOI:10.1002/hlca.201300062

Reference yield:

methyl (S)-N-(1-aza-6-oxaspiro[2.5]oct-1-en-2-yl)prolinate (323207-12-1) → 1-({4-[(4-bromobenzoyl)amino]-3,4,5,6-tetrahydro-2H-pyran-4-yl}carbonyl)-L-proline (1482285-99-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 45 h / 0 - 20 °C

2: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 23 h / 20 °C

With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol;

DOI:10.1002/hlca.201300062

upstream raw materials:

4-Bromobenzoic acid

methyl (S)-N-(1-aza-6-oxaspiro[2.5]oct-1-en-2-yl)prolinate

methyl 1-({4-[(4-bromobenzoyl)amino]-3,4,5,6-tetrahydro-2H-pyran-4-yl}carbonyl)-L-prolinate

Downstream raw materials:

methyl 1-[(4-{[1-({4-[(4-bromobenzoyl)amino]-3,4,5,6-tetrahydro-2H-pyran-4-yl}carbonyl)-L-prolyl]amino}-3,4,5,6-tetrahydro-2H-pyran-4-yl)carbonyl]-L-prolinate

1-[ (4-{[1-({4-[(4-bromobenzoyl)amino]-3,4,5,6-tetrahydro-2H-pyran-4-yl}carbonyl)-L-prolyl]amino}-3,4,5,6-tetrahydro-2H-pyran-4-yl)carbonyl]-L-proline

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