1-[ (4-{[1-({4-[(4-bromobenzoyl)amino]-3,4,5,6-tetrahydro-2H-pyran-4-yl}carbonyl)-L-prolyl]amino}-3,4,5,6-tetrahydro-2H-pyran-4-yl)carbonyl]-L-proline

Base Information

Chemical Name:1-[ (4-{[1-({4-[(4-bromobenzoyl)amino]-3,4,5,6-tetrahydro-2H-pyran-4-yl}carbonyl)-L-prolyl]amino}-3,4,5,6-tetrahydro-2H-pyran-4-yl)carbonyl]-L-proline
CAS No.:1482286-03-2
Molecular Formula:C₂₉H₃₇BrN₄O₈
Molecular Weight:649.539
Hs Code.:

Synonyms:1-[ (4-{[1-({4-[(4-bromobenzoyl)amino]-3,4,5,6-tetrahydro-2H-pyran-4-yl}carbonyl)-L-prolyl]amino}-3,4,5,6-tetrahydro-2H-pyran-4-yl)carbonyl]-L-proline

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Chemical Property of 1-[ (4-{[1-({4-[(4-bromobenzoyl)amino]-3,4,5,6-tetrahydro-2H-pyran-4-yl}carbonyl)-L-prolyl]amino}-3,4,5,6-tetrahydro-2H-pyran-4-yl)carbonyl]-L-proline

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Technology Process of 1-[ (4-{[1-({4-[(4-bromobenzoyl)amino]-3,4,5,6-tetrahydro-2H-pyran-4-yl}carbonyl)-L-prolyl]amino}-3,4,5,6-tetrahydro-2H-pyran-4-yl)carbonyl]-L-proline

There total 5 articles about 1-[ (4-{[1-({4-[(4-bromobenzoyl)amino]-3,4,5,6-tetrahydro-2H-pyran-4-yl}carbonyl)-L-prolyl]amino}-3,4,5,6-tetrahydro-2H-pyran-4-yl)carbonyl]-L-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1482286-00-9
methyl 1-[(4-{[1-({4-[(4-bromobenzoyl)amino]-3,4,5,6-tetrahydro-2H-pyran-4-yl}carbonyl)-L-prolyl]amino}-3,4,5,6-tetrahydro-2H-pyran-4-yl)carbonyl]-L-prolinate

: 1482286-03-2
1-[ (4-{[1-({4-[(4-bromobenzoyl)amino]-3,4,5,6-tetrahydro-2H-pyran-4-yl}carbonyl)-L-prolyl]amino}-3,4,5,6-tetrahydro-2H-pyran-4-yl)carbonyl]-L-proline

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃; for 25h;
DOI:10.1002/hlca.201300062

Reference yield:

: 586-76-5
4-Bromobenzoic acid

: 1482286-03-2
1-[ (4-{[1-({4-[(4-bromobenzoyl)amino]-3,4,5,6-tetrahydro-2H-pyran-4-yl}carbonyl)-L-prolyl]amino}-3,4,5,6-tetrahydro-2H-pyran-4-yl)carbonyl]-L-proline

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 45 h / 0 - 20 °C

2: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 23 h / 20 °C

3: tetrahydrofuran / 47 h / 0 - 20 °C

4: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 25 h / 20 °C

With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol;
DOI:10.1002/hlca.201300062

Reference yield:

: 323207-12-1
methyl (S)-N-(1-aza-6-oxaspiro[2.5]oct-1-en-2-yl)prolinate

: 1482286-03-2
1-[ (4-{[1-({4-[(4-bromobenzoyl)amino]-3,4,5,6-tetrahydro-2H-pyran-4-yl}carbonyl)-L-prolyl]amino}-3,4,5,6-tetrahydro-2H-pyran-4-yl)carbonyl]-L-proline

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 45 h / 0 - 20 °C

2: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 23 h / 20 °C

3: tetrahydrofuran / 47 h / 0 - 20 °C

4: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 25 h / 20 °C

With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol;
DOI:10.1002/hlca.201300062