ethyl 2-((2-((4-cyanophenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3-fluorobenzyl)amino)acetate

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Chemical Name:ethyl 2-((2-((4-cyanophenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3-fluorobenzyl)amino)acetate
CAS No.:1370706-13-0
Molecular Formula:C₂₉H₃₀FN₃O₄
Molecular Weight:503.573
Hs Code.:

Synonyms:ethyl 2-((2-((4-cyanophenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3-fluorobenzyl)amino)acetate

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Chemical Property of ethyl 2-((2-((4-cyanophenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3-fluorobenzyl)amino)acetate

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Technology Process of ethyl 2-((2-((4-cyanophenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3-fluorobenzyl)amino)acetate

There total 7 articles about ethyl 2-((2-((4-cyanophenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3-fluorobenzyl)amino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1370706-04-9
4-((6-((3-fluorobenzyl)amino)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzonitrile

: 105-36-2
ethyl bromoacetate

: 1370706-13-0
ethyl 2-((2-((4-cyanophenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3-fluorobenzyl)amino)acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 24h;
DOI:10.1016/j.ejmech.2012.01.059

Reference yield:

: 1056737-08-6
(2,4-dimethyl-6-nitro-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methanol

: 1370706-13-0
ethyl 2-((2-((4-cyanophenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3-fluorobenzyl)amino)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 48 h / Reflux

2: palladium on carbon; hydrogen / tetrahydrofuran / 2 h / 20 °C

3: sodium triacetoxyborohydride / 1,2-dichloro-ethane / 6 h / 20 °C

4: N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate / acetonitrile / 24 h / 60 °C

With sodium triacetoxyborohydride; di-isopropyl azodicarboxylate; palladium on carbon; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; potassium carbonate; triphenylphosphine; In tetrahydrofuran; 1,2-dichloro-ethane; acetonitrile; 1: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2011.06.089

Reference yield:

: 1056737-17-7
4-[(2,4-dimethyl-6-nitro-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy]benzonitrile

: 1370706-13-0
ethyl 2-((2-((4-cyanophenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3-fluorobenzyl)amino)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium on carbon; hydrogen / tetrahydrofuran / 2 h / 20 °C

2: sodium triacetoxyborohydride / 1,2-dichloro-ethane / 6 h / 20 °C

3: N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate / acetonitrile / 24 h / 60 °C

With sodium triacetoxyborohydride; palladium on carbon; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; potassium carbonate; In tetrahydrofuran; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1016/j.bmcl.2011.06.089