Carbonic acid 4-[allyl-(toluene-4-sulfonyl)-amino]-1,1-dimethyl-but-2-ynyl ester methyl ester

Base Information

• Chemical Name: Carbonic acid 4-[allyl-(toluene-4-sulfonyl)-amino]-1,1-dimethyl-but-2-ynyl ester methyl ester
• CAS No.: 191861-24-2
• Molecular Formula: C₁₈H₂₃NO₅S
• Molecular Weight: 365.45
• Mol file: 191861-24-2.mol

Synonyms:Carbonic acid 4-[allyl-(toluene-4-sulfonyl)-amino]-1,1-dimethyl-but-2-ynyl ester methyl ester

Chemical Property of Carbonic acid 4-[allyl-(toluene-4-sulfonyl)-amino]-1,1-dimethyl-but-2-ynyl ester methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of Carbonic acid 4-[allyl-(toluene-4-sulfonyl)-amino]-1,1-dimethyl-but-2-ynyl ester methyl ester

There total 2 articles about Carbonic acid 4-[allyl-(toluene-4-sulfonyl)-amino]-1,1-dimethyl-but-2-ynyl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N-tosyl-N-allylpropargylamine (133886-40-5) + methyl chloroformate (79-22-1) + acetone (67-64-1) → Carbonic acid 4-[allyl-(toluene-4-sulfonyl)-amino]-1,1-dimethyl-but-2-ynyl ester methyl ester (191861-24-2)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; for 1h; Ambient temperature; 1.) -79 deg C;

DOI:10.1002/hlca.19970800302

Reference yield:

4-methyl-N-(2-propenyl)benzenesulfonamide (50487-71-3) → Carbonic acid 4-[allyl-(toluene-4-sulfonyl)-amino]-1,1-dimethyl-but-2-ynyl ester methyl ester (191861-24-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / 1.) NaH / dimethylformamide; paraffin / 1 h / Ambient temperature; 1.) room temp., 30 min

2: 89 percent / 1.) LiHMDS / tetrahydrofuran / 1 h / Ambient temperature; 1.) -79 deg C

With sodium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; paraffin;

DOI:10.1002/hlca.19970800302

Reference yield: 93.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + carbon monoxide (201230-82-2) + Carbonic acid 4-[allyl-(toluene-4-sulfonyl)-amino]-1,1-dimethyl-but-2-ynyl ester methyl ester (191861-24-2) → 3-Methyl-2-[3-(toluene-4-sulfonyl)-3-aza-bicyclo[3.1.0]hex-1-yl]-but-2-enoic acid methyl ester

Guidance literature:

With palladium bis(dibenzylideneacetone)palladium⁽⁰⁾; trifuran-2-yl-phosphane; Product distribution; 1.) MeOH; 2.) CH₂Cl₂, Et₂O; other reag., other solvent;

DOI:10.1002/hlca.19970800302

upstream raw materials:

N-tosyl-N-allylpropargylamine

methyl chloroformate

acetone

4-methyl-N-(2-propenyl)benzenesulfonamide